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TranscriptomicsTranscription profiling by array of peripheral blood mononuclear cells from male and female patients with relapsing remitting multiple sclerosis and healthy controls
We measured global mRNA expression in peripheral blood mononuclear cells (PBMC) from 45 individuals, comprising of 23 RRMS patients and 22 healthy controls. A gender-based case-control analysis was performed to derive the differentially expressed genes (DEG) in women and men. In contrast to the dist...
ORGANISM(S): Homo sapiens 
2012-03-31 | E-MTAB-380 | biostudies-arrayexpress
TranscriptomicsGene expressions data of Multiple Sclerosis stages, Clinical Isolated Syndrome and healthy controls
Clinically Isolated Syndromes (CIS)represent the first clinical episode of an inflammatory demyelinating disorder suggestive of MS. Most CIS will develop relapsing-remitting MS (RR), characterized by clinical and inflammatory attacks followed by periods of recovery and stability. With time, most RR-...
ORGANISM(S): Homo sapiens 
2023-01-31 | E-MTAB-11415 | biostudies-arrayexpress
TranscriptomicsTrancriptional profiling in microvesicles in stimulated (M1 and M2) and unstimulated conditions
Extracellular membrane vesicles (MVs) are powerful biomarkers in several pathological processes. The potential advantage of MVs relays on the assumption that their content reflects processes ongoing in pathologically relevant cell types. Using microarrays, we performed transcriptional profiling in s...
ORGANISM(S): Mus musculus 
2016-06-03 | E-MTAB-1540 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis in Dicer knock-out mice
The precise mechanisms by which microRNAs (miRNAs) contribute to the dynamic regulation of gene expression during forebrain development are still partly elusive. Here we show that depletion of miRNAs via genetic inactivation of Dicer after the onset of forebrain neurogenesis profoundly impairs the m...
ORGANISM(S): Mus musculus 
2012-11-14 | E-MTAB-1062 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling in spinal cord of EAE mice treated with iPSC
The possibility of generating neural stem/precursor cells (NPCs) from induced pluripotent stem cells (iPSCs) has opened a new avenue of research that might nurture bench-to bedside translation of novel and more efficient protocols of cell transplantation in central nervous system (CNS) myelin disord...
ORGANISM(S): Mus musculus 
2016-06-03 | E-MTAB-1546 | biostudies-arrayexpress
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