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TranscriptomicsImplication of Long noncoding RNAs in the endothelial cell response to hypoxia II.
Long noncoding RNAs (lncRNAs) are non-protein coding RNAs regulating gene expression. Although for some lncRNAs a relevant role in hypoxic endothelium has been shown, the regulation and function of lncRNAs is still largely unknown in the vascular physio-pathology. Taking advantage of next-generation...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-76739 | biostudies-arrayexpress
TranscriptomicsHypoxia-induced miR-210 modulates gene expression in response to acute peripheral ischemia.
Peripheral Artery Disease is caused by the restriction or occlusion of arteries supplying the leg. Better understanding of the molecular mechanisms underpinning tissue response to acute and chronic ischemia is urgently needed to improve therapeutic options. The aim of this study is understanding miR...
ORGANISM(S): Mus musculus 
2015-10-23 | E-GEOD-43340 | biostudies-arrayexpress
TranscriptomicsmicroRNAs expression profile in Myotonic Dystrophy type-2 (DM2) patients
Myotonic Dystrophy Type-2 (DM2) is an autosomal dominant disease caused by the expansion of a CCTG tetraplet repeat. It is a multisystemic disorder, affecting skeletal muscles, the heart, the eye, the central nervous system and the endocrine system The expression of 365 miRNAs was measured in the mu...
ORGANISM(S): Homo sapiens 
2012-08-27 | E-GEOD-37794 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of diabetic and non diabetic patients affected by post-ischemic heart failure
Increased morbidity and mortality associated with post-ischemic heart failure (HF) in diabetic patients underscore the need for a better understanding of the underlying molecular events. Indeed, effective HF therapy in diabetic patients requires a complex strategy encompassing the development of imp...
ORGANISM(S): Homo sapiens 
2012-03-21 | E-GEOD-26887 | biostudies-arrayexpress
TranscriptomicsSmall RNA-sequencing of Fibro-Adipogenic Progenitors (FAPs) upon Histone Deacetylase inhibition in young mdx mice
Fibro-adipogenic progenitors (FAPs) are emerging cellular components of the skeletal muscle regenerative environment. The alternative functional phenotype of FAPs - either supportive of muscle regeneration or promoting fibro-adipogenic degeneration - is a key determinant in the pathogenesis of muscu...
ORGANISM(S): Mus musculus 
2014-04-23 | E-GEOD-51933 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Myotonic Dystrophy type 2 (DM2) patients.
Myotonic Dystrophy Type-2 (DM2) is an autosomal dominant disease caused by the expansion of a CCTG tetraplet repeat. It is a multisystemic disorder, affecting skeletal muscles, the heart, the eye, the central nervous system and the endocrine system. Whole mRNAs expression was measured in the muscle ...
ORGANISM(S): Homo sapiens 
2015-04-05 | E-GEOD-37084 | biostudies-arrayexpress
Unknown'Minimal symptom expression' in patients with acetylcholine receptor antibody-positive refractory generalized myasthenia gravis treated with eculizumab.
Not available
S-EPMC7320935 | biostudies-literature
UnknownLong-term safety and efficacy of eculizumab in generalized myasthenia gravis.
Not available
S-EPMC6619057 | biostudies-literature
UnknownConsistent improvement with eculizumab across muscle groups in myasthenia gravis.
Not available
S-EPMC7448154 | biostudies-literature
UnknownPost-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension.
Not available
S-EPMC7905790 | biostudies-literature
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