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ProteomicsHuman connective tissue mast cell proteome
Mast cells are hematopoietic cells that reside preferentially in tissues exposed to internal and external environments. Mast cells sense immunological, inflammatory and environmental stimuli, and can be activated to release granules and generate inflammatory mediators. Mast cell-derived products con...
ORGANISM(S): Homo sapiens (Human) 
2020-02-12 | PXD014978 | Pride
Human Fat mast cell Skin mast cell 
ProteomicsSynovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis
Mast cells are phenotypically and functionally highly heterogeneous, and their state is possibly controlled by their local microenvironment. Therefore, concrete analyses are needed to understand whether mast cells act as powerful motivators or dispensable bystanders in specific diseases. Here, we ev...
ORGANISM(S): Homo sapiens (Human) 
2024-01-07 | PXD038584 | Pride
Ra • synovial microenvironment • mast cells • mrgprx2 
TranscriptomicsThe fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes
Background/Objectives: Obese subjects have increased number of enlarged fat cells which are reduced in size but not number in post-obesity. We performed DNA methylation profiling in fat cells with the aim of identifying differentially methylated DNA sites (DMS) linked to adipose hyperplasia (many sm...
ORGANISM(S): Homo sapiens 
2015-05-06 | E-GEOD-58622 | biostudies-arrayexpress
TranscriptomicsThe epigenetic signature of subcutaneous fat cells is linked to altered expression of genes implicated in lipid metabolism in obese women
Background Obesity is associated with changes in fat cell gene expression and metabolism. What drives these changes is not well understood. We aimed to explore fat cell epigenetics, i.e., DNA methylation, as one mediator of gene regulation, in obese women. The global DNA methylome for abdominal subc...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-67024 | biostudies-arrayexpress
TranscriptomicsWTCHG - Mouse - Liver transcriptome adaptations to high fat diet
The effect of high fat diet feeding on liver gene transcription regulation was investigated in BALB/c mice using Affymetrix gene expression arrays. Expression data was determined in 5 months old male mice fed a high fat diet (40% fat) for 15 weeks. Control mice were fed a standard carbohydrate chow....
ORGANISM(S): Mus musculus 
2012-01-11 | E-MTAB-488 | biostudies-arrayexpress
TranscriptomicsLiver transcriptome comparison of divergently selected Lean and Fat mouse lines in cholesterol homeostasis, bile acids, glucose and lipoprotein metabolism
This study aimed to identify molecular basis of obesity-resistant mechanisms in the Lean line with the emphasis on lipid homeostasis. Expression profiling using custom Steroltalk v2 microarray demonstrated that Lean mice exhibit a higher hepatic expression of cholesterol synthesis genes compared to ...
ORGANISM(S): Mus musculus 
2011-10-16 | E-GEOD-24967 | biostudies-arrayexpress
TranscriptomicsEpigenetic analysis of healthy young men following a control and high-fat overfeeding diet
Genome-wide DNA methylation profiling of healthy young men following a control and high-fat overfeeding diet using Illumina's Infinium 27k Human DNA methylation Beadchip v. 1.2. DNA methylation profiles were obtained for 27,578 CpG sites in human skeletal muscle. Randomized cross-over desgin, where ...
ORGANISM(S): Homo sapiens 
2012-09-12 | E-GEOD-36166 | biostudies-arrayexpress
TranscriptomicsGlycemic index differences of high-fat diets modulate primarily lipid metabolism in murine adipose tissue
We previously reported that a low versus high glycemic index (GI) diet on a high fat (30% kcal fat) background (LGI and HGI, respectively) significantly retarded adverse health effects in C57BL/6J male mice. The LGI diet enhanced whole body insulin sensitivity and repressed high fat diet-induced bod...
ORGANISM(S): Mus musculus 
2011-09-12 | E-GEOD-26930 | biostudies-arrayexpress
TranscriptomicsHigh dietary protein decreases fat deposition induced by high-fat and high-sucrose diet in rats
High-protein diets are known to reduce adiposity in the context of high carbohydrate and Western diets. However, few studies have investigated the specific high-protein effect on lipogenesis induced by a high-sucrose (HS) diet or fat deposition induced by high-fat feeding. We aimed to determine the ...
ORGANISM(S): Rattus norvegicus 
2015-09-01 | E-GEOD-47570 | biostudies-arrayexpress
GenomicsNobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion - 16S
16S rRNA gene sequencing of colonic feces from mice fed regular chow, regular chow+nobiletin, high-fat diet or high-fat diet+nobiletin.
ORGANISM(S): Mus musculus 
2022-05-06 | E-MTAB-11551 | biostudies-arrayexpress
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