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MetabolomicsA Pathogen-Responsive Gene Cluster for Highly Modified Fatty Acids in Tomato
In response to biotic stress, plants produce suites of highly modified fatty acids that bear unusual chemical functionalities. Despite their chemical complexity and proposed roles in pathogen defense, little is known about the biosynthesis of decorated fatty acids in plants. Falcarindiol is a protot...
2022-01-17 | MTBLS1039 | MetaboLights
MetabolomicsExogenous glutamate potentiates gentamicin to kill multidrug- and carbapenem-resistant Pseudomonas aeruginosa through activating biosynthesis of unsaturated fatty acids

Antibiotic-resistant Pseudomonas aeruginosa is a major clinical challenge due to limited drug uptake. This study shows that exogenous glutamate restores gentamicin efficacy by reprogramming bacterial metabolism to enhance membrane permeability. The effect is mediated through increased biosynthesi...

2025-09-22 | MTBLS12656 | MetaboLights
MetabolomicsUntargeted Metabolomics Analysis Reveals Aberrant Long-Chain Fatty Acids Metabolism in Relapsing-Remitting Multiple Sclerosisublication title

Background: Growing evidence indicates significant alterations in fatty acid metabolism in patients with relapsing-remitting multiple sclerosis (RRMS). However, the metabolic status of long-chain fatty acids (LCFAs), including mono-unsaturated fatty acids (MUFAs) and poly-unsaturated fatty acids ...

2026-03-23 | MTBLS13949 | MetaboLights
GenomicsNCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids
Macrophage-mediated inflammation is a major contributor to obesity-associated insulin resistance. The corepressor NCoR interacts with inflammatory pathway genes in macrophages, suggesting that its removal would result in increased activity of inflammatory responses. Surprisingly, we find that macrop...
ORGANISM(S): Mus musculus 
2013-10-09 | E-GEOD-50944 | biostudies-arrayexpress
TranscriptomicsRNASeq of Developing Arabidopsis Seeds Producing Hydroxy-Fatty Acids
Arabidopsis seeds expressing the castor fatty acid hydroxylase accumulate hydroxylated fatty acids up to 17% of total fatty acids in seed triacylglycerols, however total seed oil is also reduced up to 50%. Investigations into the cause of the reduced oil phenotype through in vivo [14C]acteate and [3...
ORGANISM(S): Arabidopsis thaliana 
2014-01-10 | E-GEOD-53952 | biostudies-arrayexpress
TranscriptomicsHigh fat challenges with different fatty acids affect distinct atherogenic gene expression pathways in immune cells from lean and obese subjects
Early perturbations in vascular health can be detected by imposing subjects to a high fat (HF) challenge and measure response capacity. Subtle responses can be determined by assessment of whole-genome transcriptional changes. We aimed to magnify differences in health by comparing gene-expression cha...
ORGANISM(S): Homo sapiens 
2015-05-13 | E-GEOD-53232 | biostudies-arrayexpress
TranscriptomicsDetailed transcriptomics analysis of the effect of dietary fatty acids on gene regulation in the murine heart.
Fatty acids comprise the primary energy source for the heart and are mainly taken up via hydrolysis of circulating triglyceride-rich lipoproteins. While most of the fatty acids entering the cardiomyocyte are oxidized, a small portion is involved in altering gene transcription to modulate cardiometab...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-30495 | biostudies-arrayexpress
TranscriptomicsDetailed transcriptomics analysis of the effect of dietary fatty acids on gene regulation in the murine heart [superseries]
This SuperSeries is composed of the following subset Series: GSE30495: Detailed transcriptomics analysis of the effect of dietary fatty acids on gene regulation in the murine heart. GSE30553: Detailed transcriptomics analysis of the effect of the PPARalpha agonist Wy14,643 on gene regulation in the ...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-30649 | biostudies-arrayexpress
MetabolomicsLC-MS-based isotope tracing data supporting cholesterol- and EA2-regulated fatty acid synthesis and tumor metabolic remodeling
This study contains LC-MS-based stable isotope tracing data investigating cholesterol- and EA2-regulated tumor metabolic remodeling. The dataset includes U-13C-glucose tracing in tumor cells and D2O tracing in animal models, supporting analysis of cholesterol-driven metabolic remodeling and the supp...
2026-10-03 | MTBLS14937 | MetaboLights
TranscriptomicsTranscription profiling of mouse small intestine following a four week diet high high in polyunsaturated fatty acids of marine origin
Dietary polyunsaturated fatty acids (PUFA) act as potent natural hypolipidemics and are linked to many health benefits in humans and in animal models. Mice fed long-term a high fat diet, in which medium-chain alpha linoleic acid (ALA) was partially replaced by long-chain docosahexaenoic (DHA) and ei...
ORGANISM(S): Mus musculus 
2009-04-16 | E-GEOD-11936 | biostudies-arrayexpress
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