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ProteomicsThe ubiquitin ligase Triad1 influences myeloid leukemogenesis by regulating the integrated stress response
Increased expression of a set of homeodomain transcription factors, including HoxA10A, characterizes an adverse prognosis subtype of acute myeloid leukemia (AML). This increase in Hox expression may be found in AML with KMT2A or MYST3/CREBBP gene rearrangements, or with normal cytogenetics. Previous...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD060787 | Pride
Innate immunity Leukemia Ubiquitination E3 ubiquitin ligase Gene expression 
ProteomicsCellular Targets and the Lysine Selectivity of the HERC5 ISG15 Ligase
ISG15 is a type I interferon-induced ubiquitin-like protein modifier that functions in innateimmune responses. The single major human ISG15 ligase is HERC5 (hHERC5), a ribosome-associated HECT E3s that broadly ISGylates proteins cotranslationally. Here, we characterized the hHERC5-dependent ISGylome...
ORGANISM(S): Homo sapiens (Human) 
2024-03-05 | PXD044834 | Pride
Innate immunity Post-translational modifications Herc5 Type i interferon Isg15 Herc6 Ubiquitin-like proteins Hect e3 
ProteomicsLocal depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model
Successfully replacing damaged cartilage with tissue-engineered constructs requires integration with the host tissue and could benefit from leveraging the native tissue's intrinsic healing capacity; however, efforts are limited by a poor understanding of how cartilage repairs minor defects. Here, we...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-07-18 | PXD035246 | Pride
Proteoglycan depletion Cartilage repair Catabolic enzyme Tissue engineering 
ProteomicsBi-directional cell-pericellular matrix interactions direct stem cell fate
Modifiable hydrogels have revealed tremendous insight into how physical characteristics of cells’ 3D environment drive stem cell lineage specification. However, in native tissues, cells do not passively receive signals from their niche. Instead they actively probe and modify their pericellular space...
ORGANISM(S): Homo sapiens (Human) 
2018-11-23 | PXD009500 | Pride
Stem cells Matrix proteins Silac Lumos Orbitrap Interactions Fate 
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