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MetabolomicsMetabolomic analysis in wildtype and Isg15 knockout mice after sham or transverse aortic constriction surgery
Not available
ORGANISM(S): Mus musculus 
ST002437 | MetabolomicsWorkbench
ProteomicsISG15 counteracts Listeria monocytogenes infection
ISG15 is primarily documented as an interferon-stimulated, ubiquitin-like protein (ubl), which has anti-viral activity. Although ISG15 was the founding member of the ubl protein family, very little is known about its function. We have found that ISG15 expression in non-phagocytic cells is dramatic...
ORGANISM(S): Homo sapiens (Human) 
2015-07-24 | PXD001805 | Pride
Interferon Listeria Silac Isg15 
ProteomicsProteomics-based identification of ISG15 modification sites in vivo upon Coxsackie virus infection
ISG15 is an interferon-stimulated, ubiquitin-like protein, with anti-viral activity against several clinically relevant viruses. However, its precise mechanism of action during viral infection remains elusive. Upon infection, ISG15 conjugates to protein substrates in covalent manner. We previously f...
ORGANISM(S): Mus musculus (Mouse) Coxsackievirus 
2024-05-23 | PXD032078 | Pride
Mouse Virus Isg15 Infection Ubiquitin 
TranscriptomicsNetwork analysis identifies proinflammatory plasma cell polarization for secretion of ISG15 in human autoimmunity
Plasma cells (PCs) as effectors of humoral immunity produce immunoglobulins to match pathogenic insult. However, emerging data suggests more diverse roles for PCs as regulators of immune and inflammatory responses via secretion of factors other than immunoglobulins. The extent to which such response...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-75007 | biostudies-arrayexpress
ProteomicsUSP16 is an ISG15 cross-reactive deubiquitinase targeting a subset of metabolic pathway-related proteins
The ubiquitin-like modifier ISG15 can modulate host and viral proteins to restrict viral and microbial infections, and act as a cytokine. Its expression and conjugation are strongly up-regulated by type I interferons. Here we identify the deubiquitinating enzyme USP16 as an ISG15 cross-reactive prot...
ORGANISM(S): Homo sapiens (Human) 
2023-11-17 | PXD043553 | Pride
Usp16 Innate immunity Metabolic enzyme Isg15 
ProteomicsProteomics-based identification of ISG15 modification sites during Listeria monocytogenes infection
ISG15 is an interferon-stimulated, ubiquitin-like protein, with anti-viral and anti-bacterial activity, however its precise mechanism of action during viral or bacterial infection remains elusive. We previously found that ISG15 restricts Listeria infection both in vitro and in vivo and identified IS...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-28 | PXD011513 | Pride
Listeria infection Mice Isg15 Ubiquitin-like modification 
Proteomics,MultiomicsISG15 counteracts Listeria monocytogenes infection
ISG15 is primarily documented as an interferon-stimulated, ubiquitin-like protein (ubl), which has anti-viral activity. Although ISG15 was the founding member of the ubl protein family, very little is known about its function. We have found that ISG15 expression in non-phagocytic cells is dramatic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080750 | MassIVE
ProteomicsMapping of ISG15 interaction partners by Virotrap coupled to mass spectrometry
During infection, interferon production leads to upregulation of the interferon-stimulated gene 15 (ISG15) which encodes the ubiquitin-like protein ISG15. ISG15 has a profound role in restricting intracellular infection by viral and bacterial pathogens. It can exert its function either as a free int...
ORGANISM(S): Homo sapiens (Human) 
2021-08-16 | PXD018345 | Pride
Isg15 Virotrap Human Interactome 
ProteomicsUSP24 is an ISG15 cross-reactive deubiquitinase that mediates IFN-I production by de-ISGylating the RNA helicase MOV10
The interferon Stimulated Gene-15 (ISG15) is a ubiquitin-like modifier induced by type I Interferon (IFN-I) and plays a crucial role in the innate immune response against viral infections. ISG15 is conjugated to target proteins by an enzymatic cascade through a process called ISGylation. While USP18...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD055843 | Pride
Human Innate immunity Ubiquitomics Isg15 Immunology Usp24 
ProteomicsMapping of ISG15 interaction partners by GST pull down coupled to mass spectrometry
During infection, interferon production leads to upregulation of the interferon-stimulated gene 15 (ISG15) which encodes the ubiquitin-like protein ISG15. ISG15 has a profound role in restricting intracellular infection by viral and bacterial pathogens. It can exert its function either as a free int...
ORGANISM(S): Homo sapiens (Human) 
2021-08-16 | PXD018346 | Pride
Human Isg15 Interactome 
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