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ProteomicsMapping of ISG15 interaction partners by Virotrap coupled to mass spectrometry
During infection, interferon production leads to upregulation of the interferon-stimulated gene 15 (ISG15) which encodes the ubiquitin-like protein ISG15. ISG15 has a profound role in restricting intracellular infection by viral and bacterial pathogens. It can exert its function either as a free int...
ORGANISM(S): Homo sapiens (Human) 
2021-08-16 | PXD018345 | Pride
Isg15 Virotrap Human Interactome 
ProteomicsVirotrap-based interactome analysis of a NTR protein
Ribosome profiling has revealed translation outside of canonical coding sequences (CDSs) including translation of short upstream ORFs, long non-coding RNAs, overlapping ORFs, ORFs in UTRs or ORFs in alternative reading frames. Studies combining mass spectrometry, ribosome profiling and CRISPR-based ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-12 | PXD030216 | Pride
Virotrap Protein-protein interaction Lc-ms/ms 
ProteomicsCapturing Salmonella SspH2 Host Targets in Virus-Like Particles
In the context of host-pathogen interactions, gram-negative bacterial virulence factors, such as effectors, may be transferred from bacterial to eukaryotic host cytoplasm by multicomponent Type III protein secretion systems (T3SSs). Central to Salmonella enterica serovar Typhimurium (S. Typhimurium)...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026740 | Pride
Virotrap Effector Salmonella Ssph2 
Proteomicsprotein-protein interaction dataset TNFR1-mediated NFkB signaling
Most MS-based approaches to study protein-protein interactions require homogenization of the cells, which leads to loss of the cellular structures, dilution of proteins and formation of incorrect protein complexes. Furthermore, several purification and washing steps are needed, which can lead to the...
ORGANISM(S): Homo sapiens (Human) 
2018-11-06 | PXD009366 | Pride
Virotrap Nfkb Protein-protein interactions Tnf 
ProteomicsVirotrap-based interactome analysis of 20 pairs of N-terminal proteoforms and their canonical protein
N-terminal proteoforms stem from the same gene but differ at their N-terminus, and most of these are found to be truncated, though some are N-terminally extended caused by ribosomes starting translation from codons in the annotated 5’UTR, and/or carry modified N-termini different from those of the c...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD039171 | Pride
Virotrap Protein-protein interaction N-terminal proteoform Lc-ms/ms 
ProteomicsTGM1 interaction partners identification reveals possible TGM1 posttranslational modifiers
TGM1 is an enzyme that cross-links structural proteins in the uppermost granular layer of the epidermis to form cornified envelopes. Cornified envelopes ensure functional stratum corneum and epidermal barrier formation. It has been suggested that the activity of TGM1 is regulated on a posttranslatio...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045105 | Pride
Cell model Virotrap Skin Transglutamination Interaction partners Human Tgm1 
ProteomicsVirotrap: Abducting Protein Complexes from Mammalian Cells
Cell lysis is an inevitable step in classical affinity purification - mass spectrometry (AP-MS) strategies to map intracellular protein interactions. Cell homogenization implies a drastic change of the protein complex environment which strongly impedes comprehensive analysis. Complementary lysis con...
ORGANISM(S): Homo sapiens (Human) 
2016-04-27 | PXD000685 | Pride
Human vlp protein complex 
ProteomicsVirotrap: Abducting Protein Complexes from Mammalian Cells
Cell lysis is an inevitable step in classical affinity purification - mass spectrometry (AP-MS) strategies to map intracellular protein interactions. Cell homogenization implies a drastic change of the protein complex environment which strongly impedes comprehensive analysis. Complementary lysis con...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080790 | MassIVE
ProteomicsPhosphorylation of the multi functional signal transducer B-cell adaptor protein (BCAP) facilitates recruitment of multiple SH2/SH3 proteins including Grb2.
B-cell adaptor protein (BCAP) is a multimodular, multi-functional signal transducer that regulates signal transduction processes in leukocytes including macrophages, B-cells and T-cells. In particular BCAP acts as a negative regulator of inflammatory signaling by the Toll-like receptors. Here we cha...
ORGANISM(S): Homo sapiens (Human) 
2019-09-16 | PXD014410 | Pride
Sh2 domains Toll-like receptors Phosphoinositide 3-kinase Human cell line hek293t bcap Phosphorylation Sh3 domains 
ProteomicsOrthogonal interactome profiling of RNF41
Ring finger protein 41 (RNF41) is an E3 ubiquitin ligase involved in the ubiquitination and degradation of many proteins such as ErbB3 receptors, BRUCE and parkin. Next to this, RNF41 regulates the intracellular trafficking of certain JAK-2 associated cytokine receptors by ubiquitinating and suppres...
ORGANISM(S): Homo sapiens (Human) 
2018-03-26 | PXD007794 | Pride
Human ap-ms viortrap bioid 
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