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TranscriptomicsPAX5TEL GENE EXPRESSION IN PREBI CELLS - FAZIO G.
In the present study, we investigated PAX5TEL function in transcription processes by transduction of PAX5TEL construct in wild type preBI cells, a primary culture of immature B cells expressing endogenous wild type PAX5 protein.
ORGANISM(S): Mus musculus 
2012-11-13 | E-MEXP-3095 | biostudies-arrayexpress
TranscriptomicsNovel PAX5 fusion genes in childhood B-Cell Precursors Acute Lymphoblastic Leukemia
PAX5, a transcription factor essential for B-cell development, has been found as a frequent target of abnormalities in B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) cases, showing point mutations, deletions, as well as translocations with several partner genes. We identified four novel PAX...
ORGANISM(S): Homo sapiens 
2015-03-02 | E-MTAB-2416 | biostudies-arrayexpress
TranscriptomicsDown syndrome pediatric BCP-ALL analysis by Target Capture NGS panel
We applied a targeted NGS analysis in order to identify fusion genes in pediatric patients with Down Syndrome and affected by B-cell precursor ALL and enrolled in the AIEOP-BFM treatment protocol in Italian centers
ORGANISM(S): Homo sapiens 
2023-04-12 | E-MTAB-11686 | biostudies-arrayexpress
TranscriptomicsGut transcriptome analysis in GvHD mice (OCT samples)
Whole transcriptome profiles of gut sections explanted from allogeneic transplanted mice were evaluated,. Different groups of mice were considered: KK= Wild type mice (Balb/c), allotransplanted with CMKLR1-KO donor cells (C57BL/6)+ CMKLR1-KO monocytes (C57BL/6) KW= Wild type mice (Balb/c), allot...
ORGANISM(S): Mus musculus 
2024-10-14 | E-MTAB-12300 | biostudies-arrayexpress
TranscriptomicsGut transcriptome analysis in GvHD mice comparing CMKLR1 knockout to wildtype mice
Whole transcriptome profiles of gut sections, explanted from allogeneic transplanted mice, were evaluated. Different groups of mice were considered, comparing CMKLR1 knock out vs. Wild type mice.
ORGANISM(S): Mus musculus 
2024-10-03 | E-MTAB-12231 | biostudies-arrayexpress
TranscriptomicsEstablishment of patient-derived bone organoids to recapitulate and dissect Hurler syndrome's skeletal disease
Mucopolysaccharidosis type I is a disease caused by the mutation of the IDUA gene, encoding the alpha-L-Iduronidase enzyme. Accumulation of glycosamminoglycans (GAGs) due to IDUA deficiency results in a complex skeletal phenotype referred to as dysostosis multiplex. The cellular and molecular pathog...
ORGANISM(S): Homo sapiens 
2024-06-24 | E-MTAB-13129 | biostudies-arrayexpress
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