Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of human SHEP-SF cells expressing AICD and Fe65
The amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimerâ??s disease (AD). Processing of APP by β- and γ-secretase activities results in the production of Ã?-amyloid (AÃ?), the main constituent of Alzheimer plaques, but also in the generation of the APP intracellul...
ORGANISM(S): Homo sapiens 
2007-06-22 | E-GEOD-4097 | biostudies-arrayexpress
ProteomicsAmyloid Beta A4 Precursor Protein-binding Family B Member 1 (FE65) Interactomics Revealed Synaptic Vesicle Glycoprotein 2A (SV2A) and Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 (SERCA2) as New Binding Proteins in the Human Brain
FE65 is a cytosolic adapter protein and an important binding partner of the amyloid precursor protein (APP). Dependent on Thr668 phosphorylation in APP, which influences amyloidogenic APP processing, FE65 undergoes nuclear translocation, thereby transmitting a signal from the cell membrane to the nu...
ORGANISM(S): Homo sapiens (Human) 
2016-05-18 | PXD000437 | Pride
Brain Human Fe65 
UnknownFe65-PTB2 Dimerization Mimics Fe65-APP Interaction.
Not available
S-EPMC5425604 | biostudies-literature
GenomicsAn epigenomic role of Fe65 in the cellular response to DNA damage.
In this study, we hypothesized that the transcriptional activity of Fe65 may contribute to DNA damage pathways by regulating gene expression patterns activated in response to genotoxic stress. To address this hypothesis, we mapped the global binding profile of Fe65 by chromatin immunoprecipitation (...
ORGANISM(S): Homo sapiens 
2017-03-29 | GSE97149 | GEO
UnknownStructural and functional characterization of a novel FE65 protein product up-regulated in cognitively impaired FE65 knockout mice.
Not available
S-EPMC2809130 | biostudies-literature
UnknownFE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth.
Not available
S-EPMC4516155 | biostudies-literature
UnknownStructural basis for polyproline recognition by the FE65 WW domain.
Not available
S-EPMC2693091 | biostudies-literature
UnknownFe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage.
Not available
S-EPMC4866770 | biostudies-literature
UnknownAn epigenomic role of Fe65 in the cellular response to DNA damage.
Not available
S-EPMC4531264 | biostudies-literature
UnknownPhosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing.
Not available
S-EPMC5622059 | biostudies-literature
Sort   by:  
 Page size