Sort   by:  
 Page size 
ProteomicsIntegrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging
Aβ peptides derived from the amyloid precursor protein (APP) have been strongly implicated in the pathogenesis of Alzheimer’s disease. However, the normal function of APP and the importance of that role in neurodegenerative disease is less clear. We recovered the Drosophila ortholog of APP, Appl, in...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-10-04 | PXD041862 | Pride
Proteomics Ubiquitinomics Amyloid precursor protein like Appl Drosophila melanogaster 
ProteomicsComparative Proteomic Analysis Highlights Metabolic Dysfunction in α-synucleinopathy
The synaptic protein α-synuclein is linked through genetics and neuropathology to the pathogenesis of Parkinson’s disease and related disorders. However, the mechanisms by which α-synuclein influences disease onset and progression are incompletely understood. To identify novel pathways and potential...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-09-09 | PXD021312 | Pride
Metabolism Snca Fly Alpha synuclein aggregates Parkinsons disease 
ProteomicsThe Parkinson's disease protein alpha-synuclein is a direct modulator of Processing-bodies and mRNA stability
Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney MT, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR,Carr SA, de Jager P, Myers CL, Lindquist S, Greenmyre TJ, Bartel DP, Feany MB, Sunyaev S, Chung CY and Khurana V. Alp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-09 | MSV000089026 | MassIVE
Sort   by:  
 Page size