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TranscriptomicsPotentiation of neurotoxicity in double mutant mice with Pink1 ablation and A53T-SNCA overexpression
As the second most frequent neurodegenerative disorder of old age, ParkinsonM-bM-^@M-^Ys disease (PD) can result from autosomal dominant causes like increased alpha-synuclein (SNCA) dosage, or from autosomal recessive causes like PINK1 loss-of-function. Interactions between these triggers and their ...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-60414 | biostudies-arrayexpress
TranscriptomicsExpression and SNP data from fibroblasts, iPSCs and neurons with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative
This SuperSeries is composed of the following subset Series: GSE28365: Expression data from fibroblasts, iPSCs and neurons with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative GSE28366: SNP data from genomic DNA from a subject, fibroblasts, iPSCs and neurons w...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-28367 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of PD fibroblasts treated by SNCA expression-control RNAi.
We investigated gene expression profiles of Parkinson disease (PD) patient's fibroblasts that were treated by SNCA expression-control RNAi to see adverse effects of the RNAi treatment. The data suggested no significant adverse effects caused by the treatment. Total RNA samples prepared from PD fibro...
ORGANISM(S): Homo sapiens 
2015-06-08 | E-GEOD-64266 | biostudies-arrayexpress
ProteomicsProteome of the cortex of old Pink1-SNCA A53T double mutant Parkinson mice
Parkinson's Disease (PD) is primarily caused by aggregates of alpha synuclein (SNCA) in dopaminergic neurons of the substantia nigra, but PD is a systemic disease and may lead to PD-associated dementia complex. PD-associated encephalopathy is a late manifestation in PD patients at risk for example o...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-21 | PXD039172 | Pride
Lc-ms/ms Mutant alpha synuclein (snca-a53t) Parkinson's disease Pten-induced kinase 1 Pd-associated encephalopathy 
ProteomicsSNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids
Synucleinopathies, including Parkinson’s disease, are characterized by α-synuclein aggregation and progressive neurodegeneration, yet the early molecular events linking SNCA gene dosage to disrupted proteostasis remain poorly understood. Here, we used human midbrain organoids carrying an SNCA tri...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD063729 | Pride
Translational control Parkinson's disease (pd) Snca 
TranscriptomicsAnalysis of striatal transcriptome in transgenic mice overexpressing human wild-type alpha-synuclein
Alpha synuclein (SNCA) has been linked to neurodegenerative diseases (synucleinopathies) that include Parkinson’s disease (PD). Although the primary neurodegeneration in PD involves nigrostriatal dopaminergic neurons, more extensive yet regionally selective neurodegeneration is observed in other syn...
ORGANISM(S): Mus musculus 
2012-02-11 | E-GEOD-35723 | biostudies-arrayexpress
TranscriptomicsExpression data from fibroblasts, iPSCs and neurons with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative
A major barrier to research on Parkinson’s disease (PD) is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells (iPSCs) from patients with PD and differentiate them into neurons affected by disease. We created an iPSC model of PD caused by triplicati...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-28365 | biostudies-arrayexpress
TranscriptomicsExpression data from Parkison's iPSCs with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative
A major barrier to research on Parkinson’s disease (PD) is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells (iPSCs) from patients with PD and differentiate them into neurons affected by disease. We created an iPSC model of PD caused by triplicati...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-30792 | biostudies-arrayexpress
ProteomicsVimentin network dysregulation mediates neurite deficits in SNCA duplication Parkinson’s patient-derived midbrain neurons
Duplication of the SNCA gene (SNCADupl), linked to elevated levels of alpha-synuclein (aSyn), is a genetic cause of Parkinson's disease (PD). Our prior work with human-induced pluripotent stem cell (hiPSC)-derived midbrain neurons generated from PD SNCADupl patients identified neuritic deficits, acc...
ORGANISM(S): Homo sapiens (Human) 
2025-07-16 | PXD063433 | Pride
Snca Midbrain neurons Parkinsons disease Vimentin 
TranscriptomicsSNP data from genomic DNA from a subject, fibroblasts, iPSCs and neurons with four copies of SNCA, and genomic DNA from an unaffected first degree relative and equivalent cell lines
A major barrier to research on Parkinson’s disease (PD) is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells (iPSCs) from patients with PD and differentiate them into neurons affected by disease. We created an iPSC model of PD caused by triplicati...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-28366 | biostudies-arrayexpress
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