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TranscriptomicsThe role of vimentin in regulating genes related to EMT
To study the biological and functional role of vimentin in maintenance of the mesenchymal phenotype of mammary epithelial cells, vimentin was silenced in the non-transformed MCF10A cells and vimentin-dependent changes in gene expression were analyzed. Scrambled is the siScr-transfected control with ...
ORGANISM(S): Homo sapiens 
2010-11-18 | E-GEOD-17802 | biostudies-arrayexpress
ProteomicsRepression of PRMT5-mediated dimethylation stabilizes vimentin and promotes metastasis in MTAP-loss lung cancer
Abstract The aggressive nature and poor prognosis of lung cancer led us to explore the mechanisms driving disease progression. Utilizing our invasive cell-based model, we identified methylthioadenosine phosphorylase (MTAP) and confirmed its suppressive effects on tumorigenesis and metastasis, and pa...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD031192 | Pride
Human Dimethylation Lung cancer 
ProteomicsSalmonella effector SopB reorganizes cytoskeletal vimentin to maintain replication vacuoles for efficient infection
Subversion of the host cytoskeleton is a critical virulence mechanism used by a variety of intracellular bacterial pathogens during their infectious life cycles. Growing evidence suggests that the tactics employed by pathogens are surprisingly diverse. Using proteomic and biochemical methods, we dem...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD028785 | Pride
Human Lc-ms Vimentin S.tm 
TranscriptomicsVimentin DNA Methylation Predicts Survival in Breast Cancer
Purpose:The Vimentin gene plays a pivotal role in epithelial-to-mesenchymal transition (EMT) and is known to be over-expressed in the prognostically poor basal-like breast cancer subtype. Recent studies have reported Vimentin DNA methylation in association with poor clinical outcomes in other solid ...
ORGANISM(S): Homo sapiens 
2013-02-19 | E-GEOD-35629 | biostudies-arrayexpress
ProteomicsProteomic analysis revealed the important role of vimentin in human cervical carcinoma HeLa cells treated with gambogic acid
Gambogic acid (GA) is an anti-cancer agent in phase Ⅱb clinical trial in China. In HeLa cells, GA inhibited cell proliferation, induced cell cycle arrest at G2/M phase and apoptosis, as showed by results of MTT assay and flow cytometric analysis. Possible target-related proteins of GA were searched ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002985 | Pride
Anti-cancer Proteomics Gambogic acid Vimentin 
TranscriptomicsHost cell tropism of Propionibacterium acnes: infection scenarios differ on skin and prostate epithelia
Proprionibacterium acnes is a Gram positive bacterium found ubiquitously on human skin, where it is typically considered to assume a commensal relationship with its host. However, it is also closely associated with the skin condition acne vulgaris. More controversially, it has a postulated involveme...
ORGANISM(S): Homo sapiens 
2012-11-21 | E-GEOD-33731 | biostudies-arrayexpress
ProteomicsPhosphosite mapping on Vimentin under hypotonic stress
Giant Axonal Neuropathy (GAN) is a pediatric neurodegenerative disease caused by loss-of-function mutations in the E3 ubiquitin ligase adaptor gigaxonin, which is encoded by the GAN (KLHL16) gene. Gigaxonin regulates the degradation of multiple intermediate filament (IF) proteins, including neurofil...
ORGANISM(S): Homo sapiens (Human) 
2022-10-27 | PXD037452 | Pride
Hypotonic stress Giant axonal neuropathy Filaments Phosphorylation 
ProteomicsHuman alveolar basal epithelial A549 cells LC-MSMS
Identification of proteins interacting with vimentin in A549 cells by using LC-MSMS
ORGANISM(S): Homo sapiens (Human) 
2022-03-18 | PXD027362 | Pride
Vimentin A549 Lc-msms 
ProteomicsProteomic analysis revealed the important role of vimentin in human cervical carcinoma HeLa cells treated with gambogic acid
Gambogic acid (GA) is an anti-cancer agent in phase Ⅱb clinical trial in China. In HeLa cells, GA inhibited cell proliferation, induced cell cycle arrest at G2/M phase and apoptosis, as showed by results of MTT assay and flow cytometric analysis. Possible target-related proteins of GA were searched ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002975 | Pride
Anti-cancer Proteomics Gambogic acid Vimentin 
ProteomicsPerinuclear Vimentin-RNF26 contacts integrate ER and endosomal responses to ER stress
Compartmentalization of organelles in space and time affects their functional state and enables higher order regulation of essential cellular processes. How organellar residence is maintained in a defined area of the cell remains poorly understood. In this study, we uncover a new role for intermedia...
ORGANISM(S): Homo sapiens (Human) 
2023-09-05 | PXD040760 | Pride
Vimentin Er stress Endosomes Intermediate filaments Rnf26 
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