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ProteomicsThe ER-embedded UBE2J1/RNF26 ubiquitylation complex in spatio-temporal control of the endolysosomal pathwayThe ER-embedded UBE2J1/RNF26 ubiquitylation complex in spatio-temporal control of the endolysosomal pathway
The endolysosomal system fulfills a wide variety of cellular functions, many of which are modulated through interactions with other organelles. In particular, the ER exerts spatiotemporal constraints on the organization and motility of endosomes and lysosomes. We have recently described the ER trans...
ORGANISM(S): Homo sapiens (Human) 
2021-01-22 | PXD022104 | Pride
Endoplasmic reticulum Endosomes Ubiquitin Rnf26 Egfr Ube2j1 
ProteomicsPerinuclear Vimentin-RNF26 contacts integrate ER and endosomal responses to ER stress
Compartmentalization of organelles in space and time affects their functional state and enables higher order regulation of essential cellular processes. How organellar residence is maintained in a defined area of the cell remains poorly understood. In this study, we uncover a new role for intermedia...
ORGANISM(S): Homo sapiens (Human) 
2023-09-05 | PXD040760 | Pride
Vimentin Er stress Endosomes Intermediate filaments Rnf26 
GenomicsRNF26 promote the proliferation and metastasis of colorectal cancer cells via Wnt pathway
RNF26 promote the proliferation and metastasis of colorectal cancer cells via Wnt pathway
PRJNA1179877 | ENA
UnknownRNF26-mediated ubiquitination of TRIM21 promotes bladder cancer progression.
Not available
S-EPMC11387874 | biostudies-literature
TranscriptomicsRNF26 promote the proliferation and metastasis of colorectal cancer cells via Wnt pathway
Colorectal cancer (CRC) is the third most common malignant tumor in the world. Identification of key genes for prediction and treatment of disease course and prognosis is urgent to reduce morbidity and mortality of CRC patients. Although dysregulated Ring finger protein 26 (RNF26) expression has bee...
ORGANISM(S): Homo sapiens 
2025-04-30 | GSE280645 | GEO
UnknownRNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms.
Not available
S-EPMC4177927 | biostudies-literature
UnknownThe FOXM1/RNF26/p57 axis regulates the cell cycle to promote the aggressiveness of bladder cancer.
Not available
S-EPMC8516991 | biostudies-literature
GenomicsPTPRZ1 dephosphorylates and stabilizes RNF26 to decrease the efficacy of TKIs and PD-1 blockade in ccRCC
PTPRZ1 dephosphorylates and stabilizes RNF26 to decrease the efficacy of TKIs and PD-1 blockade in ccRCC
PRJNA1158766 | ENA
TranscriptomicsPTPRZ1 dephosphorylates and stabilizes RNF26 to decrease the efficacy of TKIs and PD-1 blockade in ccRCC
Background: ccRCC, the most prevalent pathological subtype of renal cell carcinoma, has demonstrated a proclivity for drug resistance when treated with TKIs as a monotherapy. Notably, the integration of PD-1 blockade with TKIs has significantly enhanced patient survival, thereby emerging as a frontl...
ORGANISM(S): Homo sapiens 
2025-12-01 | GSE276729 | GEO
UnknownCDK4/6 inhibitors dephosphorylate RNF26 to stabilize TSC1 and increase the sensitivity of ccRCC to mTOR inhibitors.
Not available
S-EPMC11300639 | biostudies-literature
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