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Paurocephala sauteri Enderlein, one of the most important pests of mulberry trees in the tropical and subtropical regions, the nymphs and adults of this species penetrate the veins on the back of leaves and buds of mulberry trees, nymph and female adult can secrete wax, these wax accumulated on the ...
2024-11-04 | MTBLS11229 | MetaboLights
IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency
Frontotemporal dementia (FTD) is the most common form of dementia after Alzheimer's disease and results from frontotemporal lobar degeneration (FTLD). The pathological hallmarks of FTLD are neuronal inclusions of specific, abnormally assembled proteins1. In the majority of cases, the inclusions cont...
ORGANISM(S): Homo sapiens (Human) 
2023-12-07 | PXD044821 | Pride
In human neurodegenerative diseases associated with the intracellular aggregation of Tau protein, the ordered cores of Tau filaments adopt distinct folds. Here, we analyze Tau filaments isolated from the brain of individuals affected by Prion-Protein cerebral amyloid angiopathy (PrP-CAA) and Gerstma...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025663 | Pride
Aggregation of the prion protein (PrP) and formation of PrP amyloid (APrP) is severe in some Prion diseases. In the dominantly inherited prion protein amyloidosis known as Gerstmann-Sträussler-Scheinker (GSS) disease, plaques made of PrP amyloid are a distinct feature. The TTC to TCC mutation in Pr...
ORGANISM(S): Homo sapiens (Human) 
2022-07-18 | PXD032402 | Pride
Multimodal multiscale analysis reveals flexible DNA contacts of bacterial nucleoprotein filaments
Analysis of GPM6B silenced osteogenic hMSC at gene expression level. Analysis is showing significant changes in genes involved in cytoskeleton organization and biogenesis. Immunocytochemistry confirms changed distribution of actin filaments and change in shape and in size of focal adhesions upon GP...
ORGANISM(S): Homo sapiens 
We describe a new mutant allele of the ACTIN2 gene with enhanced actin dynamics, displaying a broad array of twisting and bending phenotypes that resemble BR-treated plants. Moreover, auxin transcriptional regulation is enhanced on the mutant background, supporting the idea that shaping actin filame...
ORGANISM(S): Arabidopsis thaliana 
Perinuclear assembly of vimentin intermediate filaments induces cancer cell nuclear dysmorphia
Metabolic dysregulation is one of the most common causes of pediatric neurodegenerative disorders. However, how the disruption of ubiquitous and essential metabolic pathways predominantly affect neural tissue remains unclear. Here we use a mouse model of AMPD2 deficiency to study cellular and molecu...
ORGANISM(S): Mus musculus 
2024-01-16 | GSE253045 | GEO
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