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ProteomicsStructure of Tau filaments in Prion protein amyloidoses
In human neurodegenerative diseases associated with the intracellular aggregation of Tau protein, the ordered cores of Tau filaments adopt distinct folds. Here, we analyze Tau filaments isolated from the brain of individuals affected by Prion-Protein cerebral amyloid angiopathy (PrP-CAA) and Gerstma...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025663 | Pride
Brain Tau Gss Prp-caa Cryo-em Seeding Aprp Neurodegeneration 
UnknownStructure of Tau filaments in Prion protein amyloidoses.
Not available
S-EPMC8270882 | biostudies-literature
UnknownThe characterization of AD/PART co-pathology in CJD suggests independent pathogenic mechanisms and no cross-seeding between misfolded Aβ and prion proteins.
Not available
S-EPMC6454607 | biostudies-literature
ProteomicsLC-MSMS analysis of immunoprecipitated JunB-FLAG from HAP1 ADO KO cells
Define the N-terminal acetylation status of human JunB in siCTRL, siNAA10 or siNAA20 treated HAP1 ADO KO cells.
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD045695 | Pride
Lc-msms Human Junb 
ProteomicsBenchmarking workflows for plasma proteomics
In this project we asses 5 different sample processing workflows for mass spectrometry based plasma proteomics and compare the results with a neat plasma workflow. The workflows evaluated includes protocols for abundant protein depletion (Top14 most abundant protein depletion and protein precipitati...
ORGANISM(S): Homo sapiens (Human) 
2026-05-04 | PXD070324 | Pride
Data independent acquisition Mass spectrometry Workflow assessment Astral Extracellular vesicles Plasma proteomics Enrichment strategies Depletion strategies 
ProteomicsPlasma Proteomics Benchmarking and Optimisation/ Plasma proteomics across three generations of mass spectrometry instruments: lessons for optimising biomarker discovery
In biomarker discovery phases clinical proteomics provides large-scale identification and quantification of proteins in donor samples. For these studies plasma is the most frequently used biofluid, as it reflects both physiological and pathological states of the circulating proteome. However, the va...
ORGANISM(S): Homo sapiens (Human) 
2026-04-21 | PXD069060 | Pride
Plasma proteomics Astral Clinical proteomics Lcms 
TranscriptomicsSeqA Chip-chip analysis of E. coli MG1655 and derivatives
Chromosomes are composed of enormously long DNA molecules which must be distributed correctly as the cells grow and divide. In Escherichia coli the new DNA behind the replication forks is specifically bound by the SeqA protein. SeqA binds to GATC sequences which are methylated on the A of the old st...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2012-02-22 | E-GEOD-28280 | biostudies-arrayexpress
TranscriptomicsAnalysis of SoxNeuro gene expression changes, genome-wide binding, and comparison of SoxNeuro and Dichaete binding profiles in wild type and mutant embryos
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2014-04-23 | E-GEOD-47338 | biostudies-arrayexpress
TranscriptomicsEnvironment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities
Macrophages reside in essentially all tissues of the body and play key roles in innate and adaptive immune responses. Distinct populations of tissue macrophages also acquire context-specific functions that are important for normal tissue homeostasis. To investigate mechanisms responsible for tissue-...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-62826 | biostudies-arrayexpress
GenomicsNatural genetic variation perturbs collaborative transcription factor binding required for enhancer selection and function
Natural genetic variation between two mouse strains was used as a natural mutagenesis screen to test various aspects of the proposed model for enhancer selection and function. Chromatin marks H3K4me2, H3K27Ac, and transcription factors PU.1, C/EBPa, and p65 were assessed by ChIP-Seq and GRO-Seq and ...
ORGANISM(S): Mus musculus 
2013-10-15 | E-GEOD-46494 | biostudies-arrayexpress
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