Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

ABSTRACT: Macrophages reside in essentially all tissues of the body and play key roles in innate and adaptive immune responses. Distinct populations of tissue macrophages also acquire context-specific functions that are important for normal tissue homeostasis. To investigate mechanisms responsible for tissue-specific functions, we analyzed the transcriptomes and enhancer landscapes of brain microglia and resident macrophages of the peritoneal cavity. In addition, we exploited natural genetic variation as a genome-wide “mutagenesis” strategy to identify DNA recognition motifs for transcription factors that promote common or subset-specific binding of the macrophage lineage-determining factor PU.1. We find that distinct tissue environments drive divergent programs of gene expression by differentially

ORGANISM(S): Mus musculus

SUBMITTER: David Gosselin 

PROVIDER: E-GEOD-62826 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress