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Chemokine signaling is important for the seeding of different sites by hematopoietic stem cells during development. Serum Response Factor (SRF) controls multiple genes governing adhesion and migration, mainly by recruiting members of the Myocardin-Related Transcription Factor (MRTF) family of G-acti...
ORGANISM(S): Mus musculus 
Tau is a pathogenic protein in Alzheimer’s (AD) and other neurodegenerative diseases. The misfolding of tau into β-sheet rich elongated filaments is thought to be a key event in disease pathogenesis, followed by subsequent templated recruitment of monomeric tau into this pathogenic form. Cryo-electr...
ORGANISM(S): Homo sapiens (Human) 
2025-08-05 | PXD062343 | Pride
Phagocytes as Plaque Catalysts: Human Macrophages Generate Seeding-Competent Aβ42 Fibrils with Cross-Seeding Activity
Identification of genes that are involved in self-seeding by comparing gene expression profiles between parental MDA-MB-231 cells and seeder cells (MDA-231-S1a and S1b) 2 replicates from each sample (parental MDA-MB-231, MDA-MB-231 S1a and MDA-MB-231 S1b) were analyzed
ORGANISM(S): Homo sapiens 
Bone invigorates metstatic seeding [evolving barcode]
RNA-seq for cell populations from blastocyst seeding in pig
Tau propagation is a key driver of Alzheimer’s disease (AD), yet selective markers of seeding-competent tau remain elusive. Ubiquitin phosphorylated at Serine-65 (pS65-Ub) is a PINK1-derived stress signal that accumulates in AD with elevated tau pathology, but its functional relationship to tau seed...
ORGANISM(S): Homo sapiens (Human) 
2026-09-02 | PXD079144 | Pride
Bone invigorates metastatic seeding
A series of chips with some repeated measurments. Each chip represents a pool of 4 collagen/chondroitin sulfate tissue engineering scaffold meshes seeded with 1 x 10^6 IMR-90 Human Fibroblasts. mRNA was isolated at 30 minutes, 1, 2, 4, 8, 12, 24, 48, and 72 hours after seeding.
ORGANISM(S): Homo sapiens 
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