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GenomicsLoss of SMARCAD1 mitigates tauopathy
Loss of SMARCAD1 mitigates tauopathy
PRJNA1263027 | ENA
TranscriptomicsLCM-based microarray analysis of neuronal vulnerability in the mouse model of Sanfilippo syndrome (MPSIIIB)
Sanfilippo syndrome type B (MPS III B) is an autosomal recessive, neurodegenerative disease of children, characterized by profound mental retardation and dementia. The primary cause is mutation in the NAGLU gene, resulting in deficiency of N-acetylglucosaminidase and lysosomal accumulation of hepara...
ORGANISM(S): Mus musculus 
2009-04-22 | E-GEOD-15758 | biostudies-arrayexpress
TranscriptomicsAn Epigenetic Signature in Peripheral Blood Associated with Neurodegenerative Tauopathy and the Risk-Associated Haplotype on 17q21.31
Progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) are two neurodegenerative diseases linked, at the pathologic and genetic level, to the macrutubule associated protein tau. We identified and replicated a dose-dependent effect of the risk-associated H1 haplotype on methylation le...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-53740 | biostudies-arrayexpress
ProteomicsS-nitrosylation in P301S mouse tauopathy model
We looked to find earlier molecular changes in 2-month-old transgenic P301S mice. S-nitrosylated (SNO) proteins were identified in two brain regions, cortex and hippocampus, in P301S and Wild Type (WT) littermate control mice.
ORGANISM(S): Mus musculus (Mouse) 
2019-11-08 | PXD010106 | Pride
Tauopathy Nitric oxide Mass spectrometry S-nitrosylation Tau Alzheimer's 
ProteomicsBreakdown of neuronal glycogen protects against tauopathy by reducing oxidative stress
The abnormal presence of Microtubule-associated protein Tau (MAPT) has been documented in pathologically linked diseases, including Alzheimer's disease, frontotemporal dementia and other neurodegenerative conditions collectively referred to as tauopathies. We demonstrated that dietary restriction (D...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2023-08-10 | MSV000092637 | MassIVE
Transcriptomicsp53 prevents neurodegeneration by regulating synaptic genes
DNA damage has been implicated in neurodegenerative disorders, including Alzheimer’s disease and other tauopathies, but the consequences of genotoxic stress to postmitotic neurons are poorly understood. Here we demonstrate that p53, a key mediator of the DNA damage response, plays a neuroprotective ...
ORGANISM(S): Drosophila melanogaster 
2015-01-06 | E-GEOD-40418 | biostudies-arrayexpress
ProteomicsMicroglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy
Alzheimer’s disease is associated with disrupted circadian rhythms and clock gene expression. REV-ERBα (Nr1d1) is a circadian transcriptional repressor involved in the regulation of lipid metabolism and macrophage function. While global REV-ERBα deletion increases microglial activation and mitigates...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-09 | PXD043877 | Pride
Alzheimer’s disease Tau Circadian Microglia Rev-erbα 
TranscriptomicsLoss of SMARCAD1 mitigates tauopathy
Background Tauopathies are neurodegenerative diseases characterized by the accumulation of misfolded tau protein in Alzheimer’s disease (AD) and related dementia disorders. Identifying new strategies to treat tauopathy remains an important gap in the field. Methods Using forward and reverse genetic ...
ORGANISM(S): Caenorhabditis elegans 
2026-06-11 | GSE297216 | GEO
GenomicsKCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids
KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids
PRJNA1214220 | ENA
GenomicsMicroglia-mediated T cell Infiltration Drives Neurodegeneration in Tauopathy
Microglia-mediated T cell Infiltration Drives Neurodegeneration in Tauopathy
PRJNA916501 | ENA
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