The role of vimentin in regulating genes related to EMT
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Karoliina Vuoriluoto
PROVIDER: E-GEOD-17802 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer.
Vuoriluoto K K Haugen H H Kiviluoto S S Mpindi J-P JP Nevo J J Gjerdrum C C Tiron C C Lorens J B JB Ivaska J J
Oncogene 20101108 12
Epithelial-to-mesenchymal transition (EMT) is a critical event in the progression toward cancer metastasis. The intermediate filament protein vimentin is an important marker of EMT and a requisite regulator of mesenchymal cell migration. However, it is not known how vimentin functionally contributes to cancer cell invasion. Here, we report that ectopic expression of oncogenic H-Ras-V12G and Slug induces vimentin expression and migration in pre-malignant breast epithelial cells. Conversely, vimen ...[more]
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