Host cell tropism of Propionibacterium acnes: infection scenarios differ on skin and prostate epithelia

ABSTRACT: Proprionibacterium acnes is a Gram positive bacterium found ubiquitously on human skin, where it is typically considered to assume a commensal relationship with its host. However, it is also closely associated with the skin condition acne vulgaris. More controversially, it has a postulated involvement in infections of implanted prosthetic devices and has been isolated from malignant prostate tissues. The role of P. acnes in these pathologies remains undetermined, although both bacterial and host factors are implicated. By microarray analysis, we have identified fundamental differences in the global transcriptional profiles of keratinocyte and prostate cells to P. acnes infection. Notably, P. acnes infection of the keratinocyte cell line, HaCaT, elicited a robust, but acute inflammatory res

ORGANISM(S): Homo sapiens

SUBMITTER: Hans-Joachim Mollenkopf 

PROVIDER: E-GEOD-33731 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress