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Transcriptomicsp53 prevents neurodegeneration by regulating synaptic genes
DNA damage has been implicated in neurodegenerative disorders, including Alzheimer’s disease and other tauopathies, but the consequences of genotoxic stress to postmitotic neurons are poorly understood. Here we demonstrate that p53, a key mediator of the DNA damage response, plays a neuroprotective ...
ORGANISM(S): Drosophila melanogaster 
2015-01-06 | E-GEOD-40418 | biostudies-arrayexpress
ProteomicsComparative Proteomic Analysis Highlights Metabolic Dysfunction in α-synucleinopathy
The synaptic protein α-synuclein is linked through genetics and neuropathology to the pathogenesis of Parkinson’s disease and related disorders. However, the mechanisms by which α-synuclein influences disease onset and progression are incompletely understood. To identify novel pathways and potential...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-09-09 | PXD021312 | Pride
Metabolism Snca Fly Alpha synuclein aggregates Parkinsons disease 
ProteomicsThe Parkinson's disease protein alpha-synuclein is a direct modulator of Processing-bodies and mRNA stability
Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney MT, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR,Carr SA, de Jager P, Myers CL, Lindquist S, Greenmyre TJ, Bartel DP, Feany MB, Sunyaev S, Chung CY and Khurana V. Alp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-09 | MSV000089026 | MassIVE
GenomicsTau promotes neurodegeneration through global chromatin relaxation
We performed H3K9me2-based ChIP-seq to identify regions of the Drosophila genome that are H3K9me2-depleted due to transgenic neuronal expression of human mutant tau. Examination of H3K9me2 histone methylation in 10 day old control and tau transgenic Drosophila heads.
ORGANISM(S): Drosophila melanogaster 
2013-12-31 | E-GEOD-53719 | biostudies-arrayexpress
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