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TranscriptomicsTelomere dysfunction and fusion during the progression of chronic lymphocytic leukaemia: evidence for a telomere crisis
We performed single-molecule telomere length and telomere fusion analysis in patients at different stages of chronic lymphocytic leukaemia (CLL). Our work identified the shortest telomeres ever recorded in primary human tissue reinforcing the concept that there is significant cell division in CLL. F...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-22016 | biostudies-arrayexpress
TranscriptomicsChanges in gene expression induced by CDK9 inhibition alone and in combination with fludarabine
Using a transcriptomics approach we explored the mechanism(s) of synergy observed between CDKI-73 and fludarabine in primary CLL cells. The cytotoxic effects of CDKI-73 were associated with transcriptional inhibition of cdk9 target genes including MCL1 and XIAP. In contrast, fludarabine induced the ...
ORGANISM(S): Homo sapiens 
2013-06-25 | E-GEOD-48258 | biostudies-arrayexpress
UnknownAbdominal attacks and treatment in hereditary angioedema with C1-inhibitor deficiency.
Not available
S-EPMC4101849 | biostudies-literature
UnknownCD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia.
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S-EPMC4876311 | biostudies-literature
UnknownAttainment of Lipid Targets Following Coronary Artery Bypass Graft Surgery: Can We Do Better?
Not available
S-EPMC9133779 | biostudies-literature
UnknownRapid Analgesia for Prehospital hip Disruption (RAPID): findings from a randomised feasibility study.
Not available
S-EPMC6560881 | biostudies-literature
UnknownUtility of Hybrid Transferrin Binding Protein Antigens for Protection Against Pathogenic Neisseria Species.
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S-EPMC6389628 | biostudies-literature
UnknownIs fascia iliaca compartment block administered by paramedics for suspected hip fracture acceptable to patients? A qualitative study.
Not available
S-EPMC6937129 | biostudies-literature
UnknownParamedics' experiences of administering fascia iliaca compartment block to patients in South Wales with suspected hip fracture at the scene of injury: results of focus groups.
Not available
S-EPMC6398707 | biostudies-literature
UnknownPotential Use of Selected Natural Anti-Microbials to Control <i>Listeria monocytogenes</i> in Vacuum Packed Beef Burgers and Their Impact on Quality Attributes.
Not available
S-EPMC12029336 | biostudies-literature
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