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TranscriptomicsExpression data from CD4 single positive thymocyte subsets from C57BL/6 mice of 6-8 wks of age
After positive selection in the thymus, the newly generated single positive (SP) thymocytes are phenotypically and functionally immature and undergo apoptosis upon antigen stimulation. In the thymic medullary microenvironment, SP cells progressively acquire immunocompetence. Negative selection to r...
ORGANISM(S): Mus musculus 
2012-02-13 | E-GEOD-30083 | biostudies-arrayexpress
TranscriptomicsAmplitude modulation of androgen signaling by c-MYC [RNA-Seq]
Androgen-stimulated growth of the molecular apocrine breast cancer is mediated by an androgen receptor (AR)-regulated transcriptional program. Through profiling the genomic licalizations of AR and its co-regulators FOXA1 and TCF7L2 in MDA-MB-453 breast cancer cells, we revealed the molecular detail...
ORGANISM(S): Homo sapiens 
2013-03-16 | E-GEOD-45202 | biostudies-arrayexpress
TranscriptomicsEffect of BMP4 and noggin on gene expression in murine R1 ES cells
To confirm that the SMAD1/5- and SMAD4-associated genes are direct transcriptional regulators in mESCs in response to BMP, we treated undifferentiated R1 ES cells with BMP4 or with the BMP4 antagonist noggin, which can inhibit BMP signaling effectively for 4 h. Undifferentiated R1 ES cells were trea...
ORGANISM(S): Mus musculus 
2010-03-07 | E-GEOD-20527 | biostudies-arrayexpress
UnknownRheb promotes brown fat thermogenesis by Notch-dependent activation of the PKA signaling pathway.
Not available
S-EPMC6821354 | biostudies-literature
UnknownThe N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining.
Not available
S-EPMC9894261 | biostudies-literature
TranscriptomicsMicroRNA expression profiling of tamoxifen sensitive and resistant ER+ breast cancer cell lines
Tamoxifen is an effective anti-estrogen treatment for patients with estrogen receptor-positive (ER+) breast cancer. However, about 30% of such patients receiving tamoxifen as an adjuvant therapy experience recurrence within 15 years, and most patients with advanced disease eventually develop resista...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-56411 | biostudies-arrayexpress
ProteomicsThe N-Myc-Responsive LncRNA MILIP Promotes Non-Homologous DNA End Joining to Alleviate Genotoxic Stress in Human Neuroblastoma
lncRNAMILIP promotes the NHEJ pathway through facilitating Ku70-Ku80 heterodimerization and is involved in the resistance to DNA-damaging therapeutics in neuroblastoma cells.
ORGANISM(S): Homo Sapiens 
PXD033372 |
ProteomicsThe pan-cancer lncRNA PLANE regulates an alternative splicing program and promotes cancer pathogenesis
Proteome analysis of Biotin- PLANE pull-down assays
ORGANISM(S): Homo Sapiens 
2020-11-26 | PXD022747 |
TranscriptomicsExpression profiles in different stages of the immune response to Salmonella enterica Pullorum in the chicken spleen
Salmonella enterica PullorumM-oM-
ORGANISM(S): Gallus gallus 
2014-07-23 | E-GEOD-59663 | biostudies-arrayexpress
UnknownDispatcher-assisted cardiopulmonary resuscitation for out-of-hospital cardiac arrest patients: a site-level analysis of the PAROS trial.
Not available
S-EPMC12828423 | biostudies-literature
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