Dataset Information
The pan-cancer lncRNA PLANE regulates an alternative splicing program and promotes cancer pathogenesis
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Xudong Zhang
PROVIDER: PXD022747 | iProX | Thu Nov 26 00:00:00 GMT 2020
REPOSITORIES: iProX
Publications
The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis.
Nature communications 20210618 1
Genomic amplification of the distal portion of chromosome 3q, which encodes a number of oncogenic proteins, is one of the most frequent chromosomal abnormalities in malignancy. Here we functionally characterise a non-protein product of the 3q region, the long noncoding RNA (lncRNA) PLANE, which is upregulated in diverse cancer types through copy number gain as well as E2F1-mediated transcriptional activation. PLANE forms an RNA-RNA duplex with the nuclear receptor co-repressor 2 (NCOR2) pre-mRNA ...[more]
