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TranscriptomicsA mouse model of HIES reveals pro and anti-inflammatory functions of STAT3
Mutations of STAT3 underlie the autosomal dominant form of hyper-immunoglobulin E syndrome (HIES). STAT3 has critical roles in immune cells and thus, hematopoietic stem cell transplantation (HSCT), might be a reasonable therapeutic strategy in this disease. However, STAT3 also has critical function...
ORGANISM(S): Mus musculus 
2014-03-06 | E-GEOD-55607 | biostudies-arrayexpress
TranscriptomicsThe Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses
T-bet is a critical transcription factor for T helper 1 (Th1) cell differentiation. To study the regulation and functions of T-bet, we developed a T-bet-ZsGreen reporter mouse strain, in which GFP faithfully reflects the expression of T-bet. By using this tool, we report that signals elicited by IL...
ORGANISM(S): Mus musculus 
2012-10-04 | E-GEOD-38808 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancer brain metastases in a mouse xenograft model with vehicle of vorinostat treatment
Gene Expression Profiling of a Mouse Xenograft Model of â??Triple-Negativeâ?? Breast Cancer Brain Metastases With and Without Vorinostat Treatment. Purpose: As chemotherapy and molecular therapy improve the systemic survival of breast cancer patients, the incidence of brain metastases increases. Few...
ORGANISM(S): Homo sapiens 
2009-10-27 | E-GEOD-18544 | biostudies-arrayexpress
TranscriptomicsB cell super-enhancers and regulatory clusters recruit AID tumorigenic activity
The antibody gene mutator AID promiscuously damages oncogenes and B cell identity genes leading to chromosomal translocations and tumorigenesis. Why non-immunoglobulin loci are susceptible to AID activity is unknown. Here we study AID-mediated lesions in the context of nuclear architecture and the B...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-62063 | biostudies-arrayexpress
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