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TranscriptomicsDNA methylation data from non-immortalized lymphocyte samples from participants of the AGES Reykjavik Study
Genome-wide DNA methylation was studied to identify regions with extreme inter-individual variability, half of which show stability within-person, and some of which show covariation with body mass index consistently and are located in or near genes previously implicated in regulating body weight or ...
ORGANISM(S): Homo sapiens 
2010-09-14 | E-GEOD-23858 | biostudies-arrayexpress
TranscriptomicsDNA methylation in postmortem brain samples from autism cases and controls
We used the Illumina 450KMethylation BeadChip to measure DNA methylation at 485,512 loci across the genome for 40 postmortem brain samples. The purpose of our study was to identify differentially methylated regions (DMRs) associated with autism. Samples included 16 temporal cortex brain tissue sampl...
ORGANISM(S): Homo sapiens 
2013-12-12 | E-GEOD-53162 | biostudies-arrayexpress
TranscriptomicsChip-chip from human ES cells (H1), iPS cells (iPSC38), astrocytes (HA) and aortic endothelial cells (HAEC) with H3K9me2 antibody
Histone modification H3K9me2 is associated with gene silencing and forming large heterochromatin domains. But the micro-structure within large H3K9me2 domains and their relationship with DNA methylation remains unclear. This dataset was generated to compare with genome-wide DNA methylation data. Gen...
ORGANISM(S): Homo sapiens 
2013-02-17 | E-GEOD-37335 | biostudies-arrayexpress
TranscriptomicsEpigenome analysis of human epidermal and dermal samples with aging and sun exposure
Genome wide DNA methylation profiling of epidermal and dermal samples obtained from sun-exposed and sun-protected body sites from younger (<35 years old) and older (>60 years old) individuals. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles acro...
ORGANISM(S): Homo sapiens 
2015-03-23 | E-GEOD-51954 | biostudies-arrayexpress
TranscriptomicsEpigenome analysis of squamous cell carcinoma samples
Genome wide DNA methylation profiling of squamous cell carcinoma and location matched normal samples Bisulphite converted DNA from the 13 samples were hybridized to the Illumina Infinium 450k Human Methylation Beadchip.
ORGANISM(S): Homo sapiens 
2015-03-23 | E-GEOD-67097 | biostudies-arrayexpress
TranscriptomicsLarge organized chromatin K9-modifications (LOCKs) distinguish differentiated from embryonic stem cells
Higher eukaryotes must adapt a totipotent genome to specialized cell types with a stable but limited repertoire of functions. One potential mechanism for lineage restriction is changes in chromatin, and differentiation-related chromatin changes have been observed for individual genes. We have taken ...
ORGANISM(S): Mus musculus 
2009-01-17 | E-GEOD-13445 | biostudies-arrayexpress
TranscriptomicsDonor cell type influences the epigenome and differentiation potential of human induced pluripotent stem cells
This SuperSeries is composed of the following subset Series: GSE27134: DNA methylation data from human iPS cells, ES cells, cord blood, and keratinocytes GSE27186: Expression data of human somatic cell types and induced pluripotent stem cells GSE31742: DNA methylation data from human keratinocyte-de...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-27224 | biostudies-arrayexpress
TranscriptomicsExpression data from human iPS cells and fibroblasts
DNA methylation is often inversely correlated with gene expression. We used expression microarrays to determine the relationship between DNA methylation and gene expression in 6 iPS cell lines and the fibroblasts from which they were derived. We isolated RNA from iPS cells and fibroblasts for which ...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-18226 | biostudies-arrayexpress
TranscriptomicsDNA methylation data from mouse hematopoietic progenitors
Genome-wide DNA methylation was studied to determine the methylome map of lymphoid and myeoloid commitment from hematopoietic progenitors We used custom Nimblegen microarrays to determine the genome-wide DNA methylation in FACs purified mouse hematopoietic progeniors We isolated genomic DNA from mou...
ORGANISM(S): Mus musculus 
2010-08-14 | E-GEOD-23110 | biostudies-arrayexpress
TranscriptomicsDNA methylation data from human iPS cells and fibroblasts
DNA methylation is often inversely correlated with gene expression. We used custom Nimblegen microarrays to determine the relationship between DNA methylation and gene expression in 6 iPS cell lines and the fibroblasts from which they were derived. We isolated genomic DNA from iPS cells and fibrobla...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-18227 | biostudies-arrayexpress
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