Sort   by:  
 Page size 
TranscriptomicsDrug tolerance development of mouse Bcr/Abl pre-B ALL cells on irradiated MEFs
Although cure rates for acute lymphoblastic leukemia (ALL) have increased, development of resistance to drugs and patient relapse are common. The environment in which the leukemia cells are present during the drug treatment is known to provide significant survival benefit. Here, we have modeled this...
ORGANISM(S): Mus musculus 
2012-09-30 | E-GEOD-37286 | biostudies-arrayexpress
TranscriptomicsExpression in irradiated MEFs exposed to murine acute lymphoblastic leukemia cells
Primary pre-B acute lymphoblastic (ALL) cells do not proliferate long-term ex vivo without the presence of stromal support. We developed and use an ex vivo co-culture model, consisting of mouse leukemic pre-B Bcr/Abl-expressing ALL cells grown with mitotically inactivated mouse embryonic fibroblasts...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-33329 | biostudies-arrayexpress
GenomicsRif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead to loss of genetic information and chromosome rearrangements. The DNA repair protein p53 binding protein 1 (53BP1) protects the genome by limiting nucleolytic processing of DSBs by a mechanism that requires its ph...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-42298 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human BCR-ABL1-transformed acute lymphoblastic leukemia cells reveals Activation-induced cytidine deaminase acts as a mutator
The Philadelphia chromosome (Ph) encoding the oncogenic BCR-ABL1 kinase defines a subset of ALL with a particularly unfavorable prognosis. Acute lymphoblastic leukemia (ALL) cells are derived from B cell precursors in most cases and typically carry rearranged immunglobulin heavy chain (IGH) variable...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7182 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Analysis of Wild Type and 53BP1-/- Transcriptomes in B lymphocytes
Absence of 53BP1 influences the profile of DNA rearrangements in B lymphocytes.To determine whether the differences in translocation partner choice were due to differences in transcription, we compared the transcriptome of 53BP1 deficient and wild-type B cells by RNA-Seq and Polymerase II chromatin ...
ORGANISM(S): Mus musculus 
2013-02-12 | E-GEOD-42350 | biostudies-arrayexpress
Sort   by:  
 Page size