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TranscriptomicsTemporal transcriptional profiling of polyamine-depleted NIH3T3 cells
Polyamines are absolutely required for cell growth and proliferation. While polyamine depletion results in reversible cell cycle arrest, the actual mechanism of growth inhibition is still obscure. This work aimed at determining the cellular processes affected by reduction in the intracellular polyam...
ORGANISM(S): Mus musculus 
2012-09-11 | E-GEOD-36445 | biostudies-arrayexpress
TranscriptomicsDifferences in miRNA Detection Levels are Technology and Sequence Dependent
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-40820 | biostudies-arrayexpress
TranscriptomicsDifferences in miRNA Detection Levels are Technology and Sequence Dependent [NGS]
We undertook an integrative technological approach to compare miRNA detection capability of three high-throughput commercial platforms. We artificially introduced human precursor, 2’-O-methyl modified and mature spiked-in miRNAs in a controlled fashion into native human placenta total RNA.
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-40819 | biostudies-arrayexpress
TranscriptomicsTranscription factor Runx1 cooperates with MyoD and c-Jun to regulate the balance of myoblast proliferation/differentiation [Expression Study]
Runx1 is expressed in regenrating muscle, specifically in the muscle adult stem cells- the satellite cells. Its exact role and target genes were yet to be identified This experiment aimed at determining the Runx1 regulated genes in muscle regeneration, specifically in Satellite cells To elucidate th...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-55556 | biostudies-arrayexpress
TranscriptomicsEquivalent mutations in the eight subunits of the chaperonin CCT produce dramatically different cell phenotypes.
The eukaryotic cytoplasmic chaperonin-containing TCP-1 (CCT) is a complex formed by two back-to-back stacked hetero-octameric rings that assists the folding of actins, tubulins and other proteins in an ATP-dependent manner. Here, we decided to test the significance of the hetero-oligomeric nature o...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-30 | E-GEOD-19511 | biostudies-arrayexpress
TranscriptomicsTemporal transcriptional profiling of growth resumption following polyamine-depletion
Polyamines are absolutely required for cell growth and proliferation. While polyamine depletion results in reversible cell cycle arrest, the actual mechanism of growth inhibition is still obscure. This experiment aimed at determining the cellular processes elicited by re-addition of polyamines to po...
ORGANISM(S): Mus musculus 
2012-09-11 | E-GEOD-36664 | biostudies-arrayexpress
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