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MetabolomicsUtilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis
Characterizing the metabolic changes pertaining to hepatocellular carcinoma (HCC) in patients with liver cirrhosis is believed to contribute towards early detection, treatment, and understanding of the molecular mechanisms of HCC. In this study, we compare metabolite levels in sera of 78 HCC cases w...
MTBLS17 | MetaboLights
MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
MetabolomicsContributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer

BACKGROUND Increasing evidence implicates microbiome involvement in the development and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of gut or oral microbiota can lead to colonization in the pancreas, resulting in dysbiosis that culminates ...

2023-08-09 | MTBLS7260 | MetaboLights
ProteomicsLysine Succinylation in Human Lungs
In this study, we performed LC-MS/MS for global profiling of succinylation in 6 human lungs under normal physiological conditions. Our work will help for further study the function of succinylation modification in various physiology and pathology, as well as the energy metabolism and the regulation ...
ORGANISM(S): Homo Sapiens 
2021-11-02 | PXD029533 |
MetabolomicsMultiple biochemical indices and metabolomics of Clonorchis sinensis provide a novel interpretation of biomarkers

BACKGROUND: Clonorchiasis, an infectious disease caused by the liver fluke Clonorchis sinensis, may lead to the development of liver and gallbladder diseases, and even cholangiocarcinoma (CCA). However, the pathogenesis, host-pathogen interaction, and diagnostic markers ...

2022-06-24 | MTBLS3306 | MetaboLights
TranscriptomicsLncRNAs expression profiles in the livers of 20-month-old male HBx transgenic mice and C57BL/6 wild-type mice
The hepatitis B virus X protein (HBx) has been implicated as an oncogene in both epigenetic modifications and genetic regulation during hepatocarcinogenesis, but the underlying mechanisms are not entirely clear. Long non-coding RNAs (lncRNAs), which regulate gene expression with little or no protein...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-42185 | biostudies-arrayexpress
ProteomicsPhosphoproteome profiling of mouse liver during normal aging
Totally, fourteen two-month-old mice were used in the young group and ten eighteen-month-old mice were used in the old group. Their livers were detached for phosphoproteome analysis.
ORGANISM(S): Mus Musculus 
2021-02-21 | PXD024270 |
ProteomicsMulti-organ proteomic and phosphoproteomic landscape of K18-hACE2 mice infected with SARS-CoV-2
Eight 10-week-old female K18-hACE2 mice were equally divided into control (n = 4) and virus-infected group (n = 4). Mice in the virus-infected group were challenged with 10^5 median tissue culture infective dose (TCID50) of SARS-CoV-2 virus by intranasal inoculation and mice in the control group wer...
ORGANISM(S): Mus Musculus 
2022-07-21 | PXD035474 |
ProteomicsThe Omicron variant-associated cardiac injury mechanism in rhesus macaques is revealed by a proteome and phosphoproteomic map ( phosphoproteomic and proteome data)
Here, we identified proteins and phosphosites that were differentially regulated during infection with the Omicron variant using cardiac proteomics and phosphoproteomics. Our results demonstrate alterations in the global landscape of the cardiac proteome and phosphoproteome following infection with ...
ORGANISM(S): Macaca Mulatta 
2024-04-21 | PXD051632 |
ProteomicsQuantitative proteomics of human lung
The proteome in human lung was identified by mass spectrometry and quantified by label free method
ORGANISM(S): Homo Sapiens 
2022-08-31 | PXD036439 |
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