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TranscriptomicsFunctional Plasticity of Regulatory T Cell Function
Regulatory T cells (Tregs) can suppress a wide variety of cell types, in diverse organ sites and inflammatory conditions. While Tregs possess multiple suppressive mechanisms, the number required for maximal function is unclear. Furthermore, whether any inter-relationship orcross-regulatory mechani...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-29262 | biostudies-arrayexpress
GenomicsImmune and Metabolic Features of Brain Metastases Melanoma (Cancer Discovery) Data Access Committee
Data Access Committee EGAC00001001216
EGAC00001001216 | EGA
GenomicsMolecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases
There is a critical need to improve our understanding of the pathogenesis of -melanoma brain metastases (MBM). Thus, we performed RNA sequencing on 88 resected MBMs and 42 patient-matched extracranial metastases; tumors with sufficient tissue also underwent whole-exome sequencing, T-cell receptor se...
EGAS00001003672 | EGA
Genomicsba3dbe29-0fd7-4ee5-99b8-d69d3c381e6e - samples
The BAM files for WES and RNA seq used in the article "Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases." on cancer Discovery 2019. PMID: 30787016 PMCID: PMC6497554. Authors : Grant M Fischer, ..., Michael A Davies.
EGAD00001005046 | EGA
GenomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

We conducted whole-genome sequencing of probands from several melanoma families, identifying one individual carrying a novel germline variant (c.G1075A, NM_000248.3; p.E318K, NP_000239.1; rs149617956) in the melanoma lineage-specific oncogene MITF. While the variant cosegregated with melanoma in ...

phs000419.v1.p1 | EGA
UnknownImpact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation.
Not available
S-EPMC5105193 | biostudies-literature
TranscriptomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
We identified a novel germline mutation of the microphthalmia-associated transcription factor (MITF - E318K). This mutation was found to be present in numerous melanoma families, as well as the general population, where its association with melanoma has a significant effect. We determined the effe...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-31269 | biostudies-arrayexpress
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