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MetabolomicsGluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei
Bloodstream form African trypanosomes are thought to rely exclusively upon glycolysis, using glucose as a substrate, for ATP production. Indeed, the pathway has long been considered a potential therapeutic target to tackle the devastating and neglected tropical diseases caused by these parasites. Ho...
2018-12-10 | MTBLS706 | MetaboLights
ProteomicsA high-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC
Epitope tagging and magnetic bead enrichment were combined with SILAC quantitative proteomics to determine a high-confidence glycosome proteome for the procyclic life cycle stage of the parasite Trypanosoma brucei.
ORGANISM(S): Trypanosoma brucei 
2014-05-13 | PXD000663 | Pride
Trypanosoma brucei Orbitrap velos Ap-ms 
ProteomicsCell differentiation in Trypanosoma brucei is a bistable developmental switch requiring new protein synthesis to achieve signal memory
The life cycle of Trypanosoma brucei involves several cell differentiation transitions that allow transmission, survival and proliferation of these parasites. One of these transitions, the differentiation of growth-arrested stumpy forms in the mammalian blood into proliferating insect-stage procycli...
ORGANISM(S): Trypanosoma brucei 
2018-05-08 | PXD002165 | Pride
Phosphoproteomics Silac Differentiation Trypanosoma brucei 
UnknownInhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy.
Not available
S-EPMC4796027 | biostudies-literature
MetabolomicsCell-based and multi-omics profiling reveal dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei

Mitochondrial metabolic remodeling is a hallmark of the Trypanosoma brucei digenetic life cycle since the insect stage utilizes the cost-effective oxidative phosphorylation to generate ATP, while bloodstream cells switch to less energetically efficient aerobic glycolysis. Due to difficulties in a...

2020-08-20 | MTBLS1390 | MetaboLights
GenomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

We conducted whole-genome sequencing of probands from several melanoma families, identifying one individual carrying a novel germline variant (c.G1075A, NM_000248.3; p.E318K, NP_000239.1; rs149617956) in the melanoma lineage-specific oncogene MITF. While the variant cosegregated with melanoma in ...

phs000419.v1.p1 | EGA
UnknownThe immune microenvironment confers resistance to MAPK pathway inhibitors through macrophage-derived TNFα.
Not available
S-EPMC4184867 | biostudies-literature
UnknownProtective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys.
Not available
S-EPMC3846288 | biostudies-literature
TranscriptomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
We identified a novel germline mutation of the microphthalmia-associated transcription factor (MITF - E318K). This mutation was found to be present in numerous melanoma families, as well as the general population, where its association with melanoma has a significant effect. We determined the effe...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-31269 | biostudies-arrayexpress
UnknownA Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.
Not available
S-EPMC6346737 | biostudies-literature
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