Sort   by:  
 Page size 
MetabolomicsGluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei
Bloodstream form African trypanosomes are thought to rely exclusively upon glycolysis, using glucose as a substrate, for ATP production. Indeed, the pathway has long been considered a potential therapeutic target to tackle the devastating and neglected tropical diseases caused by these parasites. Ho...
2018-12-10 | MTBLS706 | MetaboLights
ProteomicsProbing endogenous peptide acceptor substrate specificities of TbSTT3A and TbSTT3B
We performed glycoproteomics on endogenous parasite glycoproteins using sequential endoglycosidase-H and peptide-N-glycosidase-F digestions, the latter in the presence of H2[18O]. This allowed us to assess the relative occupancies of native N-glycosylation sites by endoglycosidase-H resistant N-glyc...
ORGANISM(S): Trypanosoma brucei 
2017-09-20 | PXD007267 | Pride
Trypanosoma Glycoproteomics Oligosaccharyltransferase N-linked glycosylation Stt3 Glycoprotein biosynthesis Parasitology 
ProteomicsNovel analysis on substrate specificities of TbSTT3A and TbSTT3B by glycoproteomics
reprocessed data from Izquierdo et al, Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases
ORGANISM(S): Trypanosoma brucei 
2017-09-20 | PXD007268 | Pride
Trypanosoma Glycoproteomics Oligosaccharyltransferase N-linked glycosylation Stt3 Glycoprotein biosynthesis Parasitology 
ProteomicsTbSTT3A and TbSTT3B hetero-oligomeric complex
Directly address the oligomeric states of T. brucei STT3 subunits
ORGANISM(S): Trypanosoma brucei 
2017-09-20 | PXD007236 | Pride
Trypanosoma Glycoproteomics Oligosaccharyltransferase N-linked glycosylation Stt3 Glycoprotein biosynthesis Parasitology 
MetabolomicsCell-based and multi-omics profiling reveal dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei

Mitochondrial metabolic remodeling is a hallmark of the Trypanosoma brucei digenetic life cycle since the insect stage utilizes the cost-effective oxidative phosphorylation to generate ATP, while bloodstream cells switch to less energetically efficient aerobic glycolysis. Due to difficulties in a...

2020-08-20 | MTBLS1390 | MetaboLights
UnknownA second update on mapping the human genetic architecture of COVID-19.
Not available
S-EPMC10482689 | biostudies-literature
UnknownCommon, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.
Not available
S-EPMC8661833 | biostudies-literature
UnknownMapping the human genetic architecture of COVID-19.
Not available
S-EPMC8674144 | biostudies-literature
UnknownTiming of surgery following SARS-CoV-2 infection: an international prospective cohort study.
Not available
S-EPMC8206995 | biostudies-literature
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Not available
S-EPMC8652887 | biostudies-literature
Sort   by:  
 Page size