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TranscriptomicsGene expression profiling of BRCA1-mutated breast tumors
Background: Breast cancer is a complex disease, encompassed by different clinically and molecularly stratified entities. In 2000, Perou and colleagues demonstrated that tumor phenotypic diversity correlates with differences in global gene expression patterns, which in turn reflect aspects of the bio...
ORGANISM(S): Homo sapiens 
2009-10-14 | E-GEOD-12350 | biostudies-arrayexpress
ProteomicsExploring direct and indirect targets of current antileishmanial drugs using a novel thermal proteomics profiling approach
We have implemented a novel approach based on thermal proteome profiling (TPP) to further characterize the mode of action of antileishmanials antimony, miltefosine and amphotericin B, as well as to better understand the mechanisms of drug resistance deployed by Leishmania.
ORGANISM(S): Leishmania infantum JPCM5 
2022-07-22 | PXD034836 | Pride
Leishmania  leishmaniasis  thermal proteome profiling  drug resistance  proteomics  antimony  miltefosine  amphotericin b 
TranscriptomicsRNA-seq GLV6 overexpression during lateral root initiation in Arabidopsis thaliana
The goal of this experiment was to identify the downstream targets of the GOLVEN6 peptide signaling pathway in Arabidopsis thaliana, specifically during lateral root initiation. Using an estradiol inducible GLV6 overexpression construct in wildtype and rgi1rgi5 double mutant (mutant in receptors for...
ORGANISM(S): Arabidopsis thaliana 
2022-02-13 | E-MTAB-10891 | biostudies-arrayexpress
UnknownRelationship between maximal oxygen uptake, within-set fatigue and between-set recovery during resistance exercise in resistance-trained men and women.
Not available
S-EPMC10863198 | biostudies-literature
UnknownCharacterization and Sequencing of a Genotype XII Newcastle Disease Virus Isolated from a Peacock (Pavo cristatus) in Peru.
Not available
S-EPMC4520891 | biostudies-literature
UnknownHRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE.
Not available
S-EPMC4047212 | biostudies-literature
UnknownFasciola hepatica GST mu-class suppresses the cytokine storm induced by E. coli-lipopolysaccharide, whereas it modulates the dynamic of peritoneal macrophages in a mouse model and suppresses the classical activation of macrophages.
Not available
S-EPMC10782955 | biostudies-literature
UnknownIn Vitro Anti-proliferative and Anti-invasive Effect of Polysaccharide-rich Extracts from Trametes Versicolor and Grifola Frondosa in Colon Cancer Cells.
Not available
S-EPMC6367522 | biostudies-literature
TranscriptomicsMiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action at target tissu...
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-17058 | biostudies-arrayexpress
MetabolomicsAlignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites

Acute febrile illnesses are still a major cause of mortality and morbidity globally, particularly in low to middle income countries. The aim of this study was to determine any possible metabolic commonalities of patients infected with disparate pathogens that cause fever. Three liquid chromatogra...

2023-07-17 | MTBLS4895 | MetaboLights
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