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MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
ProteomicsEndogenous brain ARC complexes
Arc is an activity regulated neuronal protein yet little is known about its protein interactions, assembly into multiprotein complexes, role in human disease and cognition. We applied an integrated proteomic and genetic strategy using targeted tagging of a Tandem Affinity Purification (TAP) tag and ...
ORGANISM(S): Mus musculus (Mouse) 
2017-10-19 | PXD007283 | Pride
Complexes Brain Mouse Lc-ms/ms 
UnknownGαi2+ vomeronasal neurons govern the initial outcome of an acute social competition.
Not available
S-EPMC6972791 | biostudies-literature
UnknownThe Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
Not available
S-EPMC6826211 | biostudies-literature
UnknownA Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data.
Not available
S-EPMC8518716 | biostudies-literature
UnknownCognitive decline in diabetic mice predisposed to Alzheimer's disease is greater than in wild type.
Not available
S-EPMC10105330 | biostudies-literature
UnknownA53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice.
Not available
S-EPMC2898885 | biostudies-literature
UnknownHuman behaviour can trigger large carnivore attacks in developed countries.
Not available
S-EPMC4738333 | biostudies-literature
UnknownLack of AtMC1 catalytic activity triggers autoimmunity dependent on NLR stability.
Not available
S-EPMC12069761 | biostudies-literature
UnknownAortic valve replacement: validation of the Toronto Aortic Stenosis Quality of Life Questionnaire.
Not available
S-EPMC7835556 | biostudies-literature
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