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UnknownLong-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial.

Background

For women with oestrogen receptor (ER)-positive early breast cancer, treatment with tamoxifen for 5 years substantially reduces the breast cancer mortality rate throughout the first 15 years after diagnosis. We aimed to assess the further effects of continuing tamoxifen to 10 year...
S-EPMC3596060 | biostudies-literature
UnknownBreast Cancer Risk Genes - Association Analysis in More than 113,000 Women.

Background

Genetic testing for breast cancer susceptibility is widely used, but for many genes, evidence of an association with breast cancer is weak, underlying risk estimates are imprecise, and reliable subtype-specific risk estimates are lacking.

Methods

We used a panel of 34 putat...
S-EPMC7611105 | biostudies-literature
UnknownBreast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores.

Background

Recent population-based female breast cancer and prostate cancer polygenic risk scores (PRS) have been developed. We assessed the associations of these PRS with breast and prostate cancer risks for male BRCA1 and BRCA2 pathogenic variant carriers.

Methods

483 BRCA1 and 1318...
S-EPMC8755508 | biostudies-literature
UnknownPrecision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis.

Background

Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with Type 2 diabetes (T2D).

Methods

We conducted a systematic review and meta-analysis of longitudinal studies to identify potentially novel prognostic factors that m...
S-EPMC10803333 | biostudies-literature
UnknownDisease-modifying therapies and features linked to treatment response in type 1 diabetes prevention: a systematic review.

Background

Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Prevention efforts have focused on immune modulation and supporting beta cell health before or around diagnosis; however, heterogeneity in disease progression and therapy response has l...
S-EPMC10550983 | biostudies-literature
UnknownTreatment effect heterogeneity following type 2 diabetes treatment with GLP1-receptor agonists and SGLT2-inhibitors: a systematic review.

Background

A precision medicine approach in type 2 diabetes requires the identification of clinical and biological features that are reproducibly associated with differences in clinical outcomes with specific anti-hyperglycaemic therapies. Robust evidence of such treatment effect heterogenei...
S-EPMC10551026 | biostudies-literature
UnknownPrecision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus: a systematic review.

Background

The objective of this systematic review is to identify prognostic factors among women and their offspring affected by gestational diabetes mellitus (GDM), focusing on endpoints of cardiovascular disease (CVD) and type 2 diabetes (T2D) for women, and cardiometabolic profile for off...
S-EPMC10786838 | biostudies-literature
UnknownImpact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review.

Background

The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesiz...
S-EPMC10551013 | biostudies-literature
UnknownPrecision gestational diabetes treatment: a systematic review and meta-analyses.

Background

Gestational Diabetes Mellitus (GDM) affects approximately 1 in 7 pregnancies globally. It is associated with short- and long-term risks for both mother and baby. Therefore, optimizing treatment to effectively treat the condition has wide-ranging beneficial effects. However, despit...
S-EPMC10550921 | biostudies-literature
UnknownRefining the diagnosis of gestational diabetes mellitus: a systematic review and meta-analysis.

Background

Perinatal outcomes vary for women with gestational diabetes mellitus (GDM). The precise factors beyond glycemic status that may refine GDM diagnosis remain unclear. We conducted a systematic review and meta-analysis of potential precision markers for GDM.

Methods

Systematic...
S-EPMC10728189 | biostudies-literature
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