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TranscriptomicsSingle-cell RNA-seq of Endometrial organoids treated with NOTCH or WNT inhibitors in a time course of Estrogen and Progesterone stimulation
We performed single-cell RNA-sequencing of 3D endometrial organoid cultures in order to dissect the signaling pathways that determine cell fate of epithelial lineages. Every time course was obtained in a background that either included or did not include ovarian hormones stimulation, which emulates ...
ORGANISM(S): Homo sapiens 
2021-07-21 | E-MTAB-10283 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of Endometrial Superficial biopsies and full depth uterine tissue from organ donors
We performed single-cell RNA-sequencing to create a cell census of the human endometrium, which is the mucosal lining of the uterus that undergoes dynamic changes throughout the menstrual cycle. We integrated cells that were obtained from 3 superficial biopsies to selected samples that originated fr...
ORGANISM(S): Homo sapiens 
2021-07-21 | E-MTAB-10287 | biostudies-arrayexpress
TranscriptomicsDynamic Transcriptional Response of Escherichia coli to Inclusion Body Formation
DNA microarrays were used to compare the E. coli gene expression response to soluble and insoluble recombinant protein production. The study objective was to characterize the dynamic transcriptional changes that occur as insoluble recombinant protein is produced Recombinant cultures producing VP1GF...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2013-08-16 | E-GEOD-47732 | biostudies-arrayexpress
GenomicsThe Transcriptional Programme Controlled by Scl/Tal1 Gene during Early Embryonic Haematopoietic Development
The basic-helix-loop-helix transcription factor Scl/Tal1 controls the development and subsequent differentiation of haematopoietic stem cells (HSCs). However, since few Scl target genes have been validated to date, the underlying mechanisms have remained largely unknown. Here we have employed ChIP...
ORGANISM(S): Mus musculus 
2009-06-19 | E-GEOD-15806 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing resolves a CD4+ T cell fate bifurcation
Single-cell RNA sequencing (scRNA-seq) was used to study the various transcriptional states of individual CD4+ T cells during blood-stage Plasmodium chabaudi infection in mice. This is an experimental model of malaria in which CD4+ T cells are essential for controlling parasite numbers, and which is...
ORGANISM(S): Mus musculus 
2017-03-21 | E-MTAB-4388 | biostudies-arrayexpress
UnknownComprehensive functional testing in fibroblasts has strong utility to diagnose mitochondrial disease
Not available
S-SCDT-10_1038-S44321-026-00497-3 | biostudies-other
GenomicsA fully validated blood stem/progenitor cell regulatory network reveals mechanisms of cell state stabilisation
The aim of this study was to determine the genomic binding sites of important haematopoietic transcription factors in haematopoietic cell lines. 416Bs cells were fixed with either 1 or 0.4 % formaldehyde for 10 mins. Chromatin was isolated, sonicated for 7 mins (30 sec on, 30 sec off), and specific ...
ORGANISM(S): Mus musculus 
2016-03-17 | E-GEOD-69776 | biostudies-arrayexpress
GenomicsHigh-throughput single cell gene expression analysis in primary blood stem and progenitor cells identifies new links between key transcriptional regulators
Cellular decision-making is mediated by a complex interplay of external stimuli with the intracellular environment, in particular transcription factor regulatory networks. Here we have determined the expression of a network of 18 key haematopoietic transcription factors (TFs) in 597 single primary ...
ORGANISM(S): Mus musculus 
2013-04-24 | E-GEOD-42518 | biostudies-arrayexpress
GenomicsSMG
Severe malaria cases from Gambia
EGAD00000000018 | EGA
GenomicsCBC
Cord blood control samples from Gambia
EGAD00000000017 | EGA
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