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ProteomicsTFIIIC dinamically binds Alu elements to control gene expression through chromatin looping
Folding of the mammalian genome is governed by architectural proteins, such asCTCF. TFIIIC, a RNA polymerase III transcription factor, has been identified as aninsulator but its role in genome topology is totally unknown. Here, we show that TFIIICestablishes long-range genomic interactions that affe...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD011250 | Pride
Human Breast cancer Alu Tfiiic 
TranscriptomicsA unique epigenetic signature is associated with active DNA replication loci in human embryonic stem cells
The cellular epigenetic landscape changes as pluripotent stem cells differentiate to somatic cells or when differentiated cells transform to a cancerous state. These epigenetic changes are commonly correlated with differences in gene expression. Whether active DNA replication is also associated with...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-GEOD-43152 | biostudies-arrayexpress
GenomicsIn vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse (ChIP-Seq mouse)
Methylation of cytosines (5meC) is a widespread heritable DNA modification. During mammalian development, two global demethylation events are followed by waves of de novo DNA methylation. In vivo mechanisms of DNA methylation establishment are largely uncharacterized. Here we use Saccharomyces cerev...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-66910 | biostudies-arrayexpress
TranscriptomicsExpression profiles and ChIP on chip genomewide experiments with dl1500 virus (expressing WT small e1a).
Adenovirus e1a induces quiescent human cells to divide. We found that e1a causes global relocalization of the RB-proteins (RB, p130, p107) and p300/CBP histone acetyltransferases on promoters that restricts H3K18ac to a limited set of genes to stimulate cell cycling and inhibit antiviral responses a...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12045 | biostudies-arrayexpress
TranscriptomicsExpression profiles and ChIP on chip genomewide experiments with R2G mutant virus
Adenovirus e1a induces quiescent human cells to divide. We found that e1a causes global relocalization of the RB-proteins (RB, p130, p107) and p300/CBP histone acetyltransferases on promoters that restricts H3K18ac to a limited set of genes to stimulate cell cycling and inhibit antiviral responses a...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12046 | biostudies-arrayexpress
TranscriptomicsExpression profiles and ChIP on chip genomewide experiments with deltaCR2 mutant virus
Adenovirus e1a induces quiescent human cells to divide. We found that e1a causes global relocalization of the RB-proteins (RB, p130, p107) and p300/CBP histone acetyltransferases on promoters that restricts H3K18ac to a limited set of genes to stimulate cell cycling and inhibit antiviral responses a...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12047 | biostudies-arrayexpress
TranscriptomicsProfiles and ChIP on chip experiments with dl1500 virus (expressing WT small e1a), R2G and deltaCR2 mutant viruses
Adenovirus e1a induces quiescent human cells to divide. We found that e1a causes global relocalization of the RB-proteins (RB, p130, p107) and p300/CBP histone acetyltransferases on promoters that restricts H3K18ac to a limited set of genes to stimulate cell cycling and inhibit antiviral responses a...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-12543 | biostudies-arrayexpress
TranscriptomicsScl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers [RNA-seq]
Scl/Tal1 confers hemogenic competence and prevents cardiomyogenesis in embryonic endothelium. Here we show that Scl both directly activates a broad gene regulatory network required for hematopoietic stem/progenitor cell (HS/PC) development, and represses transcriptional regulators required for cardi...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-47083 | biostudies-arrayexpress
GenomicsScl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers [ChIP-seq]
Scl/Tal1 confers hemogenic competence and prevents cardiomyogenesis in embryonic endothelium. Here we show that Scl both directly activates a broad gene regulatory network required for hematopoietic stem/progenitor cell (HS/PC) development, and represses transcriptional regulators required for cardi...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-47082 | biostudies-arrayexpress
ProteomicsHaloferax volcanii proteome turn-over analysis of a LonB mutant and co-IP results with anti-LonB
The proteome turnover was examined in a conditional LonB mutant (HVLON3) of the model euryarchaeon H. volcanii under reduced (- trp) and nearly physiological (+ trp) LonB levels. HVLON3 was initially grown in minimal medium containing 14NH4Cl as nitrogen source in absence of trp and then switched to...
ORGANISM(S): Haloferax Volcanii Ds2 
2018-02-19 | PXD007061 | JPOST Repository
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