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TranscriptomicsGene expression in human myeloid cells
Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where pluripotent stem cells gradually limit their differentiation potential, generating different precursor cells which finally evolve into distinct terminally differentiated cells....
ORGANISM(S): Homo sapiens 
2008-12-10 | E-GEOD-12803 | biostudies-arrayexpress
TranscriptomicsCo-culture of human hematopoietic stem cells with osteoblasts affects mono/macrophage versus erythroid lineage choice.
Hematopoietic stem cells (HSCs) are located in the bone marrow in a specific microenvironment referred as the hematopoietic stem cell niche, where HSCs interact with a variety of stromal cells. Though several components of the stem cell niche have been identified, the regulatory mechanisms through w...
ORGANISM(S): Homo sapiens 
2013-05-10 | E-GEOD-38091 | biostudies-arrayexpress
TranscriptomicsMYB silencing in CD34+ progenitor cells
The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb in human hematopoietic lineage commitment, we studied the effects of its silencing during the commitment of human CD34+ Hematopoietic stem/progeni...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-13110 | biostudies-arrayexpress
TranscriptomicsMYB silencing in CD14-myeloblasts
The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb during the terminal differentiation of hematopoietic precursors, we studied the effects of its silencing in human primary CD14-myeloblasts, which ...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-21943 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hematopoietic stem cell subpopulations
Hematopoietic stem cell (HSC) subsets based on the CD34 expression and/or lineage markers expression
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1493 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD34+ cells and treatment with UTP and CXCL12
Homing and engraftment of hematopoietic stem cells (HSCs) to the bone marrow (BM) involve a complex interplay between chemokines, cytokines, and non-peptide molecules. Extracellular nucleotides and their cognate P2 receptors are emerging as key-factors of inflammation and related chemotactic respons...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5168 | biostudies-arrayexpress
TranscriptomicsExpression data from untreated and valproic acid (VPA) treated CD34+ Hematopoietic Stem Cells (HSCs)
Histone deacetylase (HDAC) inhibitors are widely utilized in hematopoietic malignance therapy; nevertheless, little is currently known concerning their effects on normal myelopoiesis. In order to investigate a putative interference of HDAC inhibitors in myeloid commitment of hematopoietic stem/proge...
ORGANISM(S): Homo sapiens 
2013-04-11 | E-GEOD-31283 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD43+ cells from idiopathic myelofibrosis patients vs normal individuals identifies a set of disease-associated genes and reveals the clinical significance of Wilms tumor gene 1 (WT1)
IM CD34+ vs BM CD34+ cells Experiment Overall Design: Differential gene expression profiling of CD34+ cells purified from the PB of 15 IM patients (3 distinct pools) and from the BM of 15 healthy subjects (3 distinct pools)
ORGANISM(S): Homo sapiens 
2007-11-08 | E-GEOD-3410 | biostudies-arrayexpress
TranscriptomicshMSC ATP treatment
Nucleotides triphosphates are extracellular messengers binding to specific plasma membrane receptors (P2Rs) that modulate responses as different as proliferation, differentiation, migration or cell death on several cell types including hematopoietic stem cells. Little and controversial information i...
ORGANISM(S): Homo sapiens 
2013-04-11 | E-GEOD-14566 | biostudies-arrayexpress
UnknownUpdate on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited.
Not available
S-EPMC3286387 | biostudies-literature
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