Sort   by:  
 Page size 
GenomicsIn vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse (ChIP-Seq mouse)
Methylation of cytosines (5meC) is a widespread heritable DNA modification. During mammalian development, two global demethylation events are followed by waves of de novo DNA methylation. In vivo mechanisms of DNA methylation establishment are largely uncharacterized. Here we use Saccharomyces cerev...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-66910 | biostudies-arrayexpress
GenomicsIn vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse (ChIP-Seq yeast)
Methylation of cytosines (5meC) is a widespread heritable DNA modification. During mammalian development, two global demethylation events are followed by waves of de novo DNA methylation. In vivo mechanisms of DNA methylation establishment are largely uncharacterized. Here we use Saccharomyces cerev...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-02 | E-GEOD-66909 | biostudies-arrayexpress
ProteomicsIntrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity
In development, pioneer transcription factors access silent chromatin to reveal lineage-specific gene programs. The structured DNA-binding domains of pioneer factors have been well characterized, but whether and how low-complexity intrinsically disordered regions (IDRs) affect chromatin and control ...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD043586 | Pride
Tcf-1 T-cells L1 Transcription factor Idrs 
UnknownMolecular, genetic and stem cell-mediated therapeutic strategies for spinal muscular atrophy (SMA).
Not available
S-EPMC3930406 | biostudies-literature
TranscriptomicsArabidopsis thaliana Growth is Negatively Regulated by the Class III Peroxidase AtPrx71 during Development and in Response to Cell Wall Damage
The cell wall is a crucial structure in plant cells, and modifications in its composition often have a major impact on growth and development. However, the molecular mechanisms responsible for the negative effects of cell wall alterations on plant growth are largely unknown. It was previously shown ...
ORGANISM(S): Arabidopsis thaliana 
2016-01-06 | E-GEOD-66980 | biostudies-arrayexpress
UnknowniPSC-Derived neural stem cells act via kinase inhibition to exert neuroprotective effects in spinal muscular atrophy with respiratory distress type 1.
Not available
S-EPMC4176534 | biostudies-literature
UnknownGenetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy.
Not available
S-EPMC4722730 | biostudies-literature
UnknownDifferential neuronal vulnerability identifies IGF-2 as a protective factor in ALS.
Not available
S-EPMC4867585 | biostudies-literature
UnknownSpinal muscular atrophy phenotype is ameliorated in human motor neurons by SMN increase via different novel RNA therapeutic approaches.
Not available
S-EPMC4485234 | biostudies-literature
TranscriptomicsIndolic metabolites are required for antifungal defense of the Arabidopsis mlo2 mutant
Arabidopsis thaliana genes MLO2 (Mildew resistance locus-O 2), MLO6 and MLO12 exhibit unequal genetic redundancy with respect to the modulation of defense responses against powdery mildew fungi and the control of developmental phenotypes such as premature leaf decay. We show that early chlorosis and...
ORGANISM(S): Arabidopsis thaliana 
2010-01-03 | E-GEOD-17875 | biostudies-arrayexpress
Sort   by:  
 Page size