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TranscriptomicsExpression data from WT DN3, TCF-1-deficient DN3 thymocytes, and T cell lymphomas in TCF-1-deficient animals.
TCF-1 is an HMG family transcription factor which is known to be critical for T cell development. We discovered that it has a unique role in suppressing malignant transformation of developing thymocytes at early stages. We identified ID2 and LEF-1 as key TCF-1 target genens in tumor suppression. We ...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-33292 | biostudies-arrayexpress
GenomicsTcf-1 expression in murine thymus
The DNA binding factor Tcf-1 is one of the most prominently expressed genes in thymocytes yet it's global DNA binding pattern remained unknown. Here we have assessed by ChIP-seq the Tcf-1 binding pattern in murine thymocytes. Tcf-1 ChIP-seq of 1 sample and input control.
ORGANISM(S): Mus musculus 
2013-06-12 | E-GEOD-46662 | biostudies-arrayexpress
ProteomicsIntrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity
In development, pioneer transcription factors access silent chromatin to reveal lineage-specific gene programs. The structured DNA-binding domains of pioneer factors have been well characterized, but whether and how low-complexity intrinsically disordered regions (IDRs) affect chromatin and control ...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD043586 | Pride
Tcf-1 T-cells L1 Transcription factor Idrs 
TranscriptomicsExpression data from WT and TCF-1-deficient memory CD8 T cells
TCF-1 is an HMG family transcription factor which is known to be activated by the canonical Wnt signaling pathway and modulated by other signals such as those derived from T cell receptor. We found that during CD8 T cell responses, TCF-1 deficiency impaired long-term maintenance of antigen-specific ...
ORGANISM(S): Mus musculus 
2010-10-04 | E-GEOD-20754 | biostudies-arrayexpress
TranscriptomicsGene expression data from LCMV-specific WT and Tcf7-/- follicular T helper cells
We did microarray experiments to elucidate the transcriptome changes due to TCF-1 deficiency in Tfh cells. These data clearly demonstrate that Tfh-associated genes were down-regulated in TCF-1-null Tfh cells, whereas Th1-associated signatures were up-regulated, indicating that TCF-1 initiates the Tf...
ORGANISM(S): Mus musculus 
2015-07-24 | E-GEOD-65693 | biostudies-arrayexpress
TranscriptomicsT cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling
Although transcriptional programs associated with T-cell specification and commitment have been described, the functional hierarchy and the roles of key regulators in structuring/ orchestrating these programs remain unclear. Activation of Notch signaling in uncommitted precursors by the thymic strom...
ORGANISM(S): Mus musculus 
2011-12-06 | E-GEOD-33513 | biostudies-arrayexpress
GenomicsTCF-1 mediates 3D genome reconfiguration during T cell development (HiChIP)
TCF-1 mediates 3D genome reconfiguration during T cell development (HiChIP)
PRJNA738525 | ENA
GenomicsTCF-1 mediates 3D genome reconfiguration during T cell development (HiC)
TCF-1 mediates 3D genome reconfiguration during T cell development (HiC)
PRJNA738526 | ENA
GenomicsTCF-1 regulation of CD8+ T cell chromatin accessibility
TCF-1 regulation of CD8+ T cell chromatin accessibility
PRJNA490437 | ENA
TranscriptomicsExpression data from Thymocytes of WT, TCF-1-deficient and β-catenin transgenic mice
Both TCF-1 and its coactivator β-catenin are known to be required for supporting normal double positive (DP) thymocyte survival through upregulating Bcl-xL. However, the downstream factors mediating this effect remained unknown. We used microarray to compare the global expression difference among WT...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-31371 | biostudies-arrayexpress
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