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ProteomicsA proteomic platform unveils the brain glycogen phosphorylase as a potential metabolic target for glioblastoma multiforme
In the last few years, several efforts have been ended to identify original strategies against gli-oblastoma multiforme (GBM): this requires a more detailed investigation of the molecular mechanism of GBM so that novel targets can be identified for new possible therapeutic agents. Here, using a combi...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD034933 | Pride
3-benzodiazepin-4-one Glycogen phosphorylase Proteomics 2 Target identification Glioblastoma multiforme 
ProteomicsA proteomic platform unveils PGK1 and 2 as potential target for Tatridin A
A multi-disciplinary strategy has been developed and applied for identifying Tatridin A target(s) to fully address its mechanism of action, based on drug affinity response target stability and targeted limited proteolysis. Both approaches point to the identification of PGK 1 and 2 (phospoglicerate k...
ORGANISM(S): Homo sapiens (Human) 
2023-07-31 | PXD034940 | Pride
Proteomics Natural compound Tatridin a Phosphoglicerate kinase 1 and 2 Target identification 
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