Sort   by:  
 Page size 
UnknownEfficacy and tolerability of adjunctive lacosamide in patients aged <4 years with focal seizures.

Objective

Primary objective was to evaluate efficacy of lacosamide administered concomitantly with 1-3 antiseizure medications in young children with uncontrolled focal (partial-onset) seizures.

Methods

Double-blind, parallel-group trial (SP0967: NCT02477839/2013-000717-20) conducted ...
S-EPMC10963285 | biostudies-literature
UnknownLoss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance.
Cornelia de Lange syndrome (CdLS) is a multisystem genetic disorder with distinct facies, growth failure, intellectual disability, distal limb anomalies, gastrointestinal and neurological disease. Mutations in NIPBL, encoding a cohesin regulatory protein, account for >80% of cases with typical facie...
S-EPMC4014191 | biostudies-literature
UnknownThe biogeography of the Amazonian tree flora.
We describe the geographical variation in tree species composition across Amazonian forests and show how environmental conditions are associated with species turnover. Our analyses are based on 2023 forest inventory plots (1 ha) that provide abundance data for a total of 5188 tree species. Within-pl...
S-EPMC11446918 | biostudies-literature
UnknownThe generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags.
Whereas genome sequencing defines the genetic potential of an organism, transcript sequencing defines the utilization of this potential and links the genome with most areas of biology. To exploit the information within the human genome in the fight against cancer, we have deposited some two million ...
S-EPMC263829 | biostudies-literature
UnknownFunctional composition of the Amazonian tree flora and forests.
Plants cope with the environment by displaying large phenotypic variation. Two spectra of global plant form and function have been identified: a size spectrum from small to tall species with increasing stem tissue density, leaf size, and seed mass; a leaf economics spectrum reflecting slow to fast r...
S-EPMC11876319 | biostudies-literature
UnknownUnraveling Amazon tree community assembly using Maximum Information Entropy: a quantitative analysis of tropical forest ecology.
In a time of rapid global change, the question of what determines patterns in species abundance distribution remains a priority for understanding the complex dynamics of ecosystems. The constrained maximization of information entropy provides a framework for the understanding of such complex systems...
S-EPMC9938116 | biostudies-literature
UnknownSpecies Distribution Modelling: Contrasting presence-only models with plot abundance data.
Species distribution models (SDMs) are widely used in ecology and conservation. Presence-only SDMs such as MaxEnt frequently use natural history collections (NHCs) as occurrence data, given their huge numbers and accessibility. NHCs are often spatially biased which may generate inaccuracies in SDMs....
S-EPMC5772443 | biostudies-literature
UnknownRarity of monodominance in hyperdiverse Amazonian forests.
Tropical forests are known for their high diversity. Yet, forest patches do occur in the tropics where a single tree species is dominant. Such "monodominant" forests are known from all of the main tropical regions. For Amazonia, we sampled the occurrence of monodominance in a massive, basin-wide dat...
S-EPMC6761143 | biostudies-literature
UnknownAn accessible, efficient and global approach for the large-scale sequencing of bacterial genomes.
We have developed an efficient and inexpensive pipeline for streamlining large-scale collection and genome sequencing of bacterial isolates. Evaluation of this method involved a worldwide research collaboration focused on the model organism Salmonella enterica, the 10KSG consortium. Following the op...
S-EPMC8690886 | biostudies-literature
UnknownBiased-corrected richness estimates for the Amazonian tree flora.
Amazonian forests are extraordinarily diverse, but the estimated species richness is very much debated. Here, we apply an ensemble of parametric estimators and a novel technique that includes conspecific spatial aggregation to an extended database of forest plots with up-to-date taxonomy. We show th...
S-EPMC7311553 | biostudies-literature
Sort   by:  
 Page size