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UnknownGap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells.
Intercellular communication is vital to ensure tissue and organism homeostasis and can occur directly, between neighbour cells via gap junctions (GJ), or indirectly, at longer distances, through extracellular vesicles, including exosomes. Exosomes, as intercellular carriers of messenger molecules, m...
S-EPMC4541155 | biostudies-literature
UnknownCasirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

Background

Casirivimab and imdevimab are non-competing monoclonal antibodies that bind to two different sites on the receptor binding domain of the SARS-CoV-2 spike glycoprotein, blocking viral entry into host cells. We aimed to evaluate the efficacy and safety of casirivimab and imdevimab a...
S-EPMC8830904 | biostudies-literature
UnknownPTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability.
The protein phosphatase 2A complex (PP2A), the major Ser/Thr phosphatase in the brain, is involved in a number of signalling pathways and functions, including the regulation of crucial proteins for neurodegeneration, such as alpha-synuclein, tau and LRRK2. Here, we report the identification of varia...
S-EPMC10115167 | biostudies-literature
UnknownSMPD4 regulates mitotic nuclear envelope dynamics and its loss causes microcephaly and diabetes.
Biallelic loss-of-function variants in SMPD4 cause a rare and severe neurodevelopmental disorder with progressive congenital microcephaly and early death. SMPD4 encodes a sphingomyelinase that hydrolyses sphingomyelin into ceramide at neutral pH and can thereby affect membrane lipid homeostasis. SMP...
S-EPMC10393401 | biostudies-literature
UnknownAlternative management for gynecological cancer care during the COVID-2019 pandemic: A Latin American survey.

Objective

To determine the acceptance rate of treatment alternatives for women with either preinvasive conditions or gynecologic cancers during the COVID-19 pandemic among Latin American gynecological cancer specialists.

Methods

Twelve experts in gynecological cancer designed an elect...
S-EPMC9087623 | biostudies-literature
TranscriptomicsRNA-sequencing of 465 lymphoblastoid cell lines from the 1000 Genomes
10.1038/nature12531
ORGANISM(S): Homo sapiens 
2012-11-06 | E-GEUV-1 | biostudies-arrayexpress
UnknownTandem RNA chimeras contribute to transcriptome diversity in human population and are associated with intronic genetic variants.
Chimeric RNAs originating from two or more different genes are known to exist not only in cancer, but also in normal tissues, where they can play a role in human evolution. However, the exact mechanism of their formation is unknown. Here, we use RNA sequencing data from 462 healthy individuals repre...
S-EPMC4136775 | biostudies-literature
UnknownThree-Year Sustained Clinical Efficacy of Drug-Coated Balloon Angioplasty in a Real-World Femoropopliteal Cohort.
Purpose: To report the 36-month outcomes from the prospective, multicenter, single-arm IN.PACT Global Study (ClinicalTrials.gov identifier NCT01609296) evaluating the performance of the IN.PACT Admiral drug-coated balloon (DCB) in real-world patients with femoropopliteal occlusive dise...
S-EPMC7545651 | biostudies-literature
Transcriptomicssmall RNA-sequencing of 452 lymphoblastoid cell lines from the 1000 Genomes
This RNA sequencing data set of 465 human lymphoblastoid cell line samples from the CEU, FIN, GBR, TSI and YRI populations from the 1000 Genomes sample collection was created by the Geuvadis consortium (www.geuvadis.org, http://www.geuvadis.org/web/geuvadis/our-rnaseq-project). The data is under emb...
ORGANISM(S): Homo sapiens 
2012-11-06 | E-GEUV-2 | biostudies-arrayexpress
UnknownRapid neutrophil mobilization by VCAM-1+ endothelial cell-derived extracellular vesicles.

Aims

Acute myocardial infarction rapidly increases blood neutrophils (<2 h). Release from bone marrow, in response to chemokine elevation, has been considered their source, but chemokine levels peak up to 24 h after injury, and after neutrophil elevation. This suggests that additional non-ch...
S-EPMC10022859 | biostudies-literature
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