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UnknownIdentification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum.
The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to achieve higher phenotypic resolution, we have characterized bone marrow progenitors that are committed to the group 1 IL...
S-EPMC7614094 | biostudies-literature
UnknownImmunogenicity of personalized dendritic-cell therapy in HIV-1 infected individuals under suppressive antiretroviral treatment: interim analysis from a phase II clinical trial.

Background

We developed a personalized Monocyte-Derived Dendritic-cell Therapy (MDDCT) for HIV-infected individuals on suppressive antiretroviral treatment and evaluated HIV-specific T-cell responses.

Methods

PBMCs were obtained from 10 HIV+ individuals enrolled in trial NC...
S-EPMC8753935 | biostudies-literature
UnknownGlucosylated cholesterol accumulates in atherosclerotic lesions and impacts macrophage immune response.
Atherosclerosis can be described as a local acquired lysosomal storage disorder (LSD), resulting from the build-up of undegraded material in lysosomes. Atherosclerotic foam cells accumulate cholesterol (Chol) and glycosphingolipids (GSLs) within lysosomes. This constitutes the ideal milieu for the f...
S-EPMC12197965 | biostudies-literature
UnknownCholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo inflammation.
Oxidation of PUFAs in LDLs trapped in the arterial intima plays a critical role in atherosclerosis. Though there have been many studies on the atherogenicity of oxidized derivatives of PUFA-esters of cholesterol, the effects of cholesteryl hemiesters (ChEs), the oxidation end products of these ester...
S-EPMC10450993 | biostudies-literature
UnknownBurden of influenza-associated respiratory hospitalizations in the Americas, 2010-2015.

Background

Despite having influenza vaccination policies and programs, countries in the Americas underutilize seasonal influenza vaccine, in part because of insufficient evidence about severe influenza burden. We aimed to estimate the annual burden of influenza-associated respiratory hospita...
S-EPMC6730873 | biostudies-literature
UnknownMultifaceted Strategy Based on Automated Text Messaging After a Recent Heart Failure Admission: The MESSAGE-HF Randomized Clinical Trial.

Importance

Readmissions after an index heart failure (HF) hospitalization are a major contemporary health care problem.

Objective

To evaluate the feasibility and efficacy of an intensive telemonitoring strategy in the vulnerable period after an HF hospitalization.

Design, setting, ...

S-EPMC10701668 | biostudies-literature
UnknownEpidemiological characterization of rare diseases in Brazil: A retrospective study of the Brazilian Rare Diseases Network.

Background

The Brazilian Policy for Comprehensive Care for People with Rare Diseases was implemented in 2014; however, national epidemiological data on rare diseases (RDs) are scarce and mainly focused on specific disorders. To address this gap, University Hospitals, Reference Services for N...
S-EPMC11523578 | biostudies-literature
UnknownResuscitation fluid practices in Brazilian intensive care units: a secondary analysis of Fluid-TRIPS.

Objective

To describe fluid resuscitation practices in Brazilian intensive care units and to compare them with those of other countries participating in the Fluid-TRIPS.

Methods

This was a prospective, international, cross-sectional, observational study in a convenience sample of inte...
S-EPMC8275089 | biostudies-literature
UnknownUpdated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.

Background & aims

Over the last decade, clinical experiences and research studies raised concerns regarding use of proton pump inhibitors (PPIs) as part of the diagnostic strategy for eosinophilic esophagitis (EoE). We aimed to clarify the use of PPIs in the evaluation and treatment of child...
S-EPMC6174113 | biostudies-literature
UnknownGlobal variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c.
Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and wh...
S-EPMC10667106 | biostudies-literature
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