Sort   by:  
 Page size 
UnknownAnti-tumor necrosis factor therapy is associated with attenuated humoral response to SARS-COV-2 vaccines in patients with inflammatory bowel disease.

Background

Immunosuppressive therapy used in the treatment of inflammatory bowel disease (IBD) is known to reduce vaccine immunogenicity.

Aims

This study aimed to 1) predict the humoral response elicited by SARS-CoV-2 vaccination in IBD patients based on their ongoing treatment and ot...
S-EPMC10165058 | biostudies-literature
UnknownCOVID-19 and obesity: a systematic review and meta-analysis on the pre-existing clinical conditions, COVID-19 symptoms, laboratory findings and clinical outcomes.
Not available
S-EPMC8743833 | biostudies-literature
UnknownCombined Influence of EGF+61G>A and TGFB+869T>C Functional Polymorphisms in Renal Cell Carcinoma Progression and Overall Survival: The Link to Plasma Circulating MiR-7 and MiR-221/222 Expression.
The epidermal growth factor (EGF) is responsible for the activation of intracellular signal transducers that act on cell-cycle progression, cell motility, angiogenesis and inhibition of apoptosis. However, cells can block these effects activating opposite signaling pathways, such as the transforming...
S-EPMC4409046 | biostudies-literature
ProteomicsExercise training decreases the load and changes the content of circulating SDS-resistant protein aggregates in patients with heart failure with reduced ejection fraction
Heart failure (HF) is often associated with the deterioration of the protein quality control (PQC) system and the accumulation of protein aggregates. Evidence from tissue biopsies showed that exercise restores PQC system in HF; however, little is known about its effects on plasma proteostasis. Our s...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045161 | Pride
Hfref  exercise training  protein aggregates  proteomics 
UnknownE4BP4 Safeguards Brown Fat Mitochondria from Obesity-Induced Fragmentation via Ceramide Repression
Brown adipose tissue (BAT) counteracts obesity-related metabolic dysfunction through both thermogenic and non-thermogenic means. However, substantial evidence indicates that obesity negatively affects BAT mitochondrial morphology and oxidative capacity, impairing systemic energy homeostasis. Motivat...
S-SCDT-10_1038-S44319-026-00826-0 | biostudies-other
UnknownViral genetics and transmission dynamics in the second wave of mpox outbreak in Portugal and forecasting public health scenarios.
In 2023, a second wave of the global mpox epidemic, which is mainly affecting men who have sex with men (MSM), was observed in some countries. Herein, we benefited from a large viral sequence sampling (76/121; 63%) and vast epidemiological data to characterise the re-emergence and circulation of the...
S-EPMC11486115 | biostudies-literature
UnknownViral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal.
Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dy...
S-EPMC10579057 | biostudies-literature
UnknownPerformance of cryptogenic new onset refractory status epilepticus score in a Brazilian cohort after testing for antineuronal antibodies with tissue-based and cell-based assays.

Objective

This study was undertaken to describe a case series of Brazilian new onset refractory status epilepticus (NORSE) patients and evaluate the sensitivity and specificity of a clinical score to predict cryptogenic etiology (c-NORSE score) after autoimmune encephalitis (AE) testing.

...

S-EPMC12291003 | biostudies-literature
UnknownPotential and limitations of machine meta-learning (ensemble) methods for predicting COVID-19 mortality in a large inhospital Brazilian dataset.
The majority of early prediction scores and methods to predict COVID-19 mortality are bound by methodological flaws and technological limitations (e.g., the use of a single prediction model). Our aim is to provide a thorough comparative study that tackles those methodological issues, considering mul...
S-EPMC9975879 | biostudies-literature
UnknownA cluster randomized trial of a multifaceted quality improvement intervention in Brazilian intensive care units: study protocol.

Background

The uptake of evidence-based therapies in the intensive care environment is suboptimal, particularly in limited-resource countries. Checklists, daily goal assessments, and clinician prompts may improve compliance with best practice processes of care and, in turn, improve clinical ...
S-EPMC4342101 | biostudies-literature
Sort   by:  
 Page size