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TranscriptomicsmiR-200 overexpression in colorectal cancer lines
Unsupervised classification of gene expression profiles has resulted in the identification of biologically and clinically distinct colon cancer subtypes (CCSs). The subtype that associates with poor clinical outcome displays a mesenchymal gene expression profile. No driver mutation has been identifi...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-65551 | biostudies-arrayexpress
TranscriptomicsAMC tubular and serrated adenomas
Profiling project of a panel of tubular adenoma and serrated adenoma patient material collected in the Academic Medical Center (AMC) in Amsterdam, The Netherlands. The aim of the study was to compare the expression profiles of different types of colon cancer precursor lesions (tubular versus serrate...
ORGANISM(S): Homo sapiens 
2013-04-14 | E-GEOD-45270 | biostudies-arrayexpress
TranscriptomicsTGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype [organoids]
The aim of this study was to determine the effects of TGFβ at the premalignant stage of CRC development. Organoid cultures were isolated from normal colon and from tubular adenomas. One normal colon culture was genetically engineered using the CRISPR-Cas9 system to carry the BRAFV600E mutation. Org...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-79461 | biostudies-arrayexpress
TranscriptomicsTGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype [adenomas]
Colorectal cancer can be divided into four consensus molecular subtypes, which might associate with distinct precursor lesions. The aim of this study was to determine the subtype affiliation of two types of colorectal adenomas: tubular adenomas (TAs) and sessile serrated adenomas (SSAs) and to deter...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-79460 | biostudies-arrayexpress
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