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TranscriptomicsEfficient cellular fractionation of RNA
The aim of this experiment was to develop new methods to extract pure fractions of nuclear and cytoplasmic RNA. We compared the results of nuclear and cytoplasmic RNA-sequencing to results of the total and polyA+ RNA-sequencing. Cytoplasmic, nuclear, total and polyA+ RNA was extracted from two human...
ORGANISM(S): Homo sapiens 
2013-10-22 | E-MTAB-1898 | biostudies-arrayexpress
GenomicsSchizophrenia Team Data Access Committee
Data Access Committee EGAC00001001471
EGAC00001001471 | EGA
TranscriptomicsHigh-resolution copy number analysis of medulloblastoma
We used high-resolution SNP genotyping to identify regions of genomic gain and loss in the genome of 212 medulloblastomas, a malignant pediatric brain tumor. Focal amplifications of fifteen known oncogenes and focal deletions of twenty known tumor suppressor genes (TSG) were revealed, most not prev...
ORGANISM(S): Homo sapiens 
2010-04-06 | E-GEOD-14437 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of DNA from humans from different populations in self-self hybridizations, replicate experiments and independent validations of copy number variations to assess array performance
Data generated in the validation of a large-insert clone DNA microarray covering the entire human genome in tiling path resolution, which we have used to identify copy number variation in human populations. Array performance was extensively tested by a series of validation assays. These included...
ORGANISM(S): Homo sapiens 
2006-08-14 | E-TABM-123 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of human blood samples spiked with one or two copies of individual human chromosomes to assess array performance
Data generated in the validation of a large-insert clone DNA microarray covering the entire human genome in tiling path resolution, which we have used to identify copy number variation in human populations. Array performance was extensively tested by a series of validation assays. These included...
ORGANISM(S): Homo sapiens 
2006-08-14 | E-TABM-124 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of 269 individuals from three geographically distinct human populations to investigate copy number variation
We conducted comparative genome hybridization experiments to catalogue the common copy number variation evident between 269 individuals from three geographically distinct human populations (Yoruban, Chinese/Japanese, European) against a single reference individual.
ORGANISM(S): Homo sapiens 
2006-07-31 | E-TABM-107 | biostudies-arrayexpress
no omics definedTiling path analysis to determine copy-number variation in 40 Utah/Morman and Yoruban population samples using NimbleGen technology
A copy-number variation (CNV) analysis was run on 40 CEU and YRI samples across an array set tiling across the human genome. The array contained 42 million oligos spread across 20 arrays. The final design provided 1 probe per 50bp average density across the genome.

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ORGANISM(S): Homo sapiens 
2009-04-01 | E-MTAB-40 | biostudies-arrayexpress
TranscriptomicsGenotyping of human copy-number variation using Agilent 2x105K
Copy-number variation (CNV) genotyping was run on 450 HapMap samples using a custom targeted array. The array contained 105 000 oligos targeted to about 10 000 CNVs.
ORGANISM(S): Homo sapiens 
2009-10-07 | E-MTAB-142 | biostudies-arrayexpress
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