Comparative genomic hybridization of 269 individuals from three geographically distinct human populations to investigate copy number variation
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Dan Andrews
PROVIDER: E-TABM-107 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Global variation in copy number in the human genome.
Redon Richard R Ishikawa Shumpei S Fitch Karen R KR Feuk Lars L Perry George H GH Andrews T Daniel TD Fiegler Heike H Shapero Michael H MH Carson Andrew R AR Chen Wenwei W Cho Eun Kyung EK Dallaire Stephanie S Freeman Jennifer L JL González Juan R JR Gratacòs Mònica M Huang Jing J Kalaitzopoulos Dimitrios D Komura Daisuke D MacDonald Jeffrey R JR Marshall Christian R CR Mei Rui R Montgomery Lyndal L Nishimura Kunihiro K Okamura Kohji K Shen Fan F Somerville Martin J MJ Tchinda Joelle J Valsesia Armand A Woodwark Cara C Yang Fengtang F Zhang Junjun J Zerjal Tatiana T Zhang Jane J Armengol Lluis L Conrad Donald F DF Estivill Xavier X Tyler-Smith Chris C Carter Nigel P NP Aburatani Hiroyuki H Lee Charles C Jones Keith W KW Scherer Stephen W SW Hurles Matthew E ME
Nature 20061101 7118
Copy number variation (CNV) of DNA sequences is functionally significant but has yet to be fully ascertained. We have constructed a first-generation CNV map of the human genome through the study of 270 individuals from four populations with ancestry in Europe, Africa or Asia (the HapMap collection). DNA from these individuals was screened for CNV using two complementary technologies: single-nucleotide polymorphism (SNP) genotyping arrays, and clone-based comparative genomic hybridization. A tota ...[more]
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