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TranscriptomicsEarly transcriptional changes linked to naturally occurring Huntington's disease mutations in human embryonic stem cells
Multiple human embryonic stem (ES) cell lines derived from blastocysts diagnosed as carrying the mutant huntingtin gene by pre-implantation diagnosis were used to explore early developmental changes in gene expression. How mutant huntingtin impacts on signalling pathways in the pre-symptomatic perio...
ORGANISM(S): Homo sapiens 
2012-06-19 | E-GEOD-34201 | biostudies-arrayexpress
TranscriptomicsHuman ES cells reveal recurrent genomic instability at 20q11.21
By analyzing five human embryonic stem (hES) cell lines over long-term culture, we detected a recurrent genomic instability in the human genome. An amplification of 2.5–4.6 Mb at 20q11.21, encompassing about 23 genes in common, appeared in four cell lines of different origins. This amplification, ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-13565 | biostudies-arrayexpress
TranscriptomicsRecurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells
array-CGH analysis of human neural stem cells derived from human ES cells during long term in vitro culture array-CGH analysis of human neural stem cells derived from human ES cells comparing control genomic DNA
ORGANISM(S): Homo sapiens 
2012-01-25 | E-GEOD-33708 | biostudies-arrayexpress
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