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MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 21)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3003 | MetaboLights
MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 10)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3056 | MetaboLights
MetabolomicsThe metabolomic resetting effect of FG4592 in AKI to CKD transition (Part 1)
Not available
ORGANISM(S): Mus musculus 
ST001855 | MetabolomicsWorkbench
MetabolomicsThe metabolomic resetting effect of FG4592 in AKI to CKD transition (Part 2)
Not available
ORGANISM(S): Mus musculus 
ST001856 | MetabolomicsWorkbench
GenomicsTreatment of infected Syrian hamsters with FG-4592
Treatment of infected Syrian hamsters with FG-4592
PRJNA802537 | ENA
UnknownThe Roxadustat (FG-4592) ameliorates tubulointerstitial fibrosis by promoting intact FGF23 cleavage.
Not available
S-EPMC12032739 | biostudies-literature
UnknownFG-4592 protects the intestine from irradiation-induced injury by targeting the TLR4 signaling pathway.
Not available
S-EPMC9210818 | biostudies-literature
UnknownAntianemia Drug Roxadustat (FG-4592) Protects Against Doxorubicin-Induced Cardiotoxicity by Targeting Antiapoptotic and Antioxidative Pathways.
Not available
S-EPMC7419679 | biostudies-literature
UnknownRoxadustat (FG-4592) Facilitates Recovery From Renal Damage by Ameliorating Mitochondrial Dysfunction Induced by Folic Acid.
Not available
S-EPMC8915431 | biostudies-literature
UnknownHypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against renal ischemia/reperfusion injury by inhibiting inflammation.
Not available
S-EPMC8118507 | biostudies-literature
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